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Beneficial and harmful effects of sacubitril/valsartan in patients with heart failure: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Current guidelines recommend angiotensin receptor blocker neprilysin inhibitors (ARNI) (sacubitril/valsartan) as a replacement for angiotensin-converting-enzymeinhibitor (ACE-I) in heart failure with reduced ejection fraction (HFrEF) who remain symptomatic despite optimal medical therapy. The effect...

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Detalles Bibliográficos
Autores principales:	Nielsen, Emil Eik, Feinberg, Joshua Buron, Bu, Fan-Long, Hecht Olsen, Michael, Raymond, Ilan, Steensgaard-Hansen, Frank, Jakobsen, Janus Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Heart Failure and Cardiomyopathies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705560/ https://www.ncbi.nlm.nih.gov/pubmed/33257469 http://dx.doi.org/10.1136/openhrt-2020-001294

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