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Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review
Combined small cell lung cancer (c‐SCLC) is a relatively rare subtype of SCLC and is defined by the combination of SCLC and any elements of non‐small cell carcinoma (NSCLC). Standard chemotherapy for patients with c‐SCLC has not yet been established. Gene mutations such as epidermal growth factor re...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705627/ https://www.ncbi.nlm.nih.gov/pubmed/33103386 http://dx.doi.org/10.1111/1759-7714.13716 |
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author | Niitsu, Takayuki Shiroyama, Takayuki Miyake, Kotaro Noda, Yoshimi Kido, Kansuke Hara, Reina Enomoto, Takatoshi Adachi, Yuichi Amiya, Saori Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Hirata, Haruhiko Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi |
author_facet | Niitsu, Takayuki Shiroyama, Takayuki Miyake, Kotaro Noda, Yoshimi Kido, Kansuke Hara, Reina Enomoto, Takatoshi Adachi, Yuichi Amiya, Saori Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Hirata, Haruhiko Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi |
author_sort | Niitsu, Takayuki |
collection | PubMed |
description | Combined small cell lung cancer (c‐SCLC) is a relatively rare subtype of SCLC and is defined by the combination of SCLC and any elements of non‐small cell carcinoma (NSCLC). Standard chemotherapy for patients with c‐SCLC has not yet been established. Gene mutations such as epidermal growth factor receptor (EGFR) mutations may be detected in patients with c‐SCLC. However, little is known about anaplastic lymphoma kinase (ALK) rearrangement in c‐SCLC patients. Here, we report a young female patient who was successfully treated with alectinib for ALK‐positive c‐SCLC after failure of immunochemotherapy for SCLC and cytotoxic chemotherapy for adenocarcinoma. Moreover, we performed a literature review of EGFR‐ or ALK‐positive c‐SCLC patients. Our report suggests that ALK testing may be justified in patients with SCLC that contain an adenocarcinoma component. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: • This is the first report describing the treatment course comprising immunochemotherapy and ALK‐TKI in a patient with c‐SCLC harboring ALK rearrangement. WHAT THIS STUDY ADDS: • Our case and literature review suggest that although ALK mutation is rare in patients with c‐SCLC, its identification and treatment with ALK‐TKIs may contribute to clinical benefits. |
format | Online Article Text |
id | pubmed-7705627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-77056272020-12-09 Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review Niitsu, Takayuki Shiroyama, Takayuki Miyake, Kotaro Noda, Yoshimi Kido, Kansuke Hara, Reina Enomoto, Takatoshi Adachi, Yuichi Amiya, Saori Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Hirata, Haruhiko Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi Thorac Cancer Case Reports Combined small cell lung cancer (c‐SCLC) is a relatively rare subtype of SCLC and is defined by the combination of SCLC and any elements of non‐small cell carcinoma (NSCLC). Standard chemotherapy for patients with c‐SCLC has not yet been established. Gene mutations such as epidermal growth factor receptor (EGFR) mutations may be detected in patients with c‐SCLC. However, little is known about anaplastic lymphoma kinase (ALK) rearrangement in c‐SCLC patients. Here, we report a young female patient who was successfully treated with alectinib for ALK‐positive c‐SCLC after failure of immunochemotherapy for SCLC and cytotoxic chemotherapy for adenocarcinoma. Moreover, we performed a literature review of EGFR‐ or ALK‐positive c‐SCLC patients. Our report suggests that ALK testing may be justified in patients with SCLC that contain an adenocarcinoma component. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: • This is the first report describing the treatment course comprising immunochemotherapy and ALK‐TKI in a patient with c‐SCLC harboring ALK rearrangement. WHAT THIS STUDY ADDS: • Our case and literature review suggest that although ALK mutation is rare in patients with c‐SCLC, its identification and treatment with ALK‐TKIs may contribute to clinical benefits. John Wiley & Sons Australia, Ltd 2020-10-25 2020-12 /pmc/articles/PMC7705627/ /pubmed/33103386 http://dx.doi.org/10.1111/1759-7714.13716 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Niitsu, Takayuki Shiroyama, Takayuki Miyake, Kotaro Noda, Yoshimi Kido, Kansuke Hara, Reina Enomoto, Takatoshi Adachi, Yuichi Amiya, Saori Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Hirata, Haruhiko Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review |
title | Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review |
title_full | Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review |
title_fullStr | Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review |
title_full_unstemmed | Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review |
title_short | Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review |
title_sort | combined small cell lung carcinoma harboring alk rearrangement: a case report and literature review |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705627/ https://www.ncbi.nlm.nih.gov/pubmed/33103386 http://dx.doi.org/10.1111/1759-7714.13716 |
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