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Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals

The aim of this study was to investigate the test–retest (TRT) repeatability of various parametric quantification methods for [(18)F]Flortaucipir positron emission tomography (PET). We included eight subjects with dementia or mild cognitive impairment due to Alzheimer’s disease and six cognitively n...

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Autores principales: Timmers, Tessa, Ossenkoppele, Rik, Visser, Denise, Tuncel, Hayel, Wolters, Emma E, Verfaillie, Sander CJ, van der Flier, Wiesje M, Boellaard, Ronald, Golla, Sandeep SV, van Berckel, Bart NM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705644/
https://www.ncbi.nlm.nih.gov/pubmed/31575335
http://dx.doi.org/10.1177/0271678X19879226
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author Timmers, Tessa
Ossenkoppele, Rik
Visser, Denise
Tuncel, Hayel
Wolters, Emma E
Verfaillie, Sander CJ
van der Flier, Wiesje M
Boellaard, Ronald
Golla, Sandeep SV
van Berckel, Bart NM
author_facet Timmers, Tessa
Ossenkoppele, Rik
Visser, Denise
Tuncel, Hayel
Wolters, Emma E
Verfaillie, Sander CJ
van der Flier, Wiesje M
Boellaard, Ronald
Golla, Sandeep SV
van Berckel, Bart NM
author_sort Timmers, Tessa
collection PubMed
description The aim of this study was to investigate the test–retest (TRT) repeatability of various parametric quantification methods for [(18)F]Flortaucipir positron emission tomography (PET). We included eight subjects with dementia or mild cognitive impairment due to Alzheimer’s disease and six cognitively normal subjects. All underwent two 130-min dynamic [(18)F]Flortaucipir PET scans within 3 ± 1 weeks. Data were analyzed using reference region models receptor parametric mapping (RPM), simplified reference tissue method 2 (SRTM2) and reference logan (RLogan), as well as standardized uptake value ratios (SUVr, time intervals 40–60, 80–100 and 110–130 min post-injection) with cerebellar gray matter as reference region. We obtained distribution volume ratio or SUVr, first for all brain regions and then in three tau-specific regions-of-interest (ROIs). TRT repeatability (%) was defined as |retest–test|/(average (test + retest)) × 100. For all methods and across ROIs, TRT repeatability ranged from (median (IQR)) 0.84% (0.68–2.15) to 6.84% (2.99–11.50). TRT repeatability was good for all reference methods used, although semi-quantitative models (i.e. SUVr) performed marginally worse than quantitative models, for instance TRT repeatability of RPM: 1.98% (0.78–3.58) vs. SUVr(80–100): 3.05% (1.28–5.52), p < 0.001. Furthermore, for SUVr(80–100) and SUVr(110–130), with higher average SUVr, more variation was observed. In conclusion, while TRT repeatability was good for all models used, quantitative methods performed slightly better than semi-quantitative methods.
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spelling pubmed-77056442020-12-08 Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals Timmers, Tessa Ossenkoppele, Rik Visser, Denise Tuncel, Hayel Wolters, Emma E Verfaillie, Sander CJ van der Flier, Wiesje M Boellaard, Ronald Golla, Sandeep SV van Berckel, Bart NM J Cereb Blood Flow Metab Original Articles The aim of this study was to investigate the test–retest (TRT) repeatability of various parametric quantification methods for [(18)F]Flortaucipir positron emission tomography (PET). We included eight subjects with dementia or mild cognitive impairment due to Alzheimer’s disease and six cognitively normal subjects. All underwent two 130-min dynamic [(18)F]Flortaucipir PET scans within 3 ± 1 weeks. Data were analyzed using reference region models receptor parametric mapping (RPM), simplified reference tissue method 2 (SRTM2) and reference logan (RLogan), as well as standardized uptake value ratios (SUVr, time intervals 40–60, 80–100 and 110–130 min post-injection) with cerebellar gray matter as reference region. We obtained distribution volume ratio or SUVr, first for all brain regions and then in three tau-specific regions-of-interest (ROIs). TRT repeatability (%) was defined as |retest–test|/(average (test + retest)) × 100. For all methods and across ROIs, TRT repeatability ranged from (median (IQR)) 0.84% (0.68–2.15) to 6.84% (2.99–11.50). TRT repeatability was good for all reference methods used, although semi-quantitative models (i.e. SUVr) performed marginally worse than quantitative models, for instance TRT repeatability of RPM: 1.98% (0.78–3.58) vs. SUVr(80–100): 3.05% (1.28–5.52), p < 0.001. Furthermore, for SUVr(80–100) and SUVr(110–130), with higher average SUVr, more variation was observed. In conclusion, while TRT repeatability was good for all models used, quantitative methods performed slightly better than semi-quantitative methods. SAGE Publications 2019-10-01 2020-12 /pmc/articles/PMC7705644/ /pubmed/31575335 http://dx.doi.org/10.1177/0271678X19879226 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Timmers, Tessa
Ossenkoppele, Rik
Visser, Denise
Tuncel, Hayel
Wolters, Emma E
Verfaillie, Sander CJ
van der Flier, Wiesje M
Boellaard, Ronald
Golla, Sandeep SV
van Berckel, Bart NM
Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals
title Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals
title_full Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals
title_fullStr Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals
title_full_unstemmed Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals
title_short Test–retest repeatability of [(18)F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals
title_sort test–retest repeatability of [(18)f]flortaucipir pet in alzheimer’s disease and cognitively normal individuals
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705644/
https://www.ncbi.nlm.nih.gov/pubmed/31575335
http://dx.doi.org/10.1177/0271678X19879226
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