Cargando…
Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study
BACKGROUND: Detecting coronary vulnerable plaques in vivo and assessing their vulnerability have been great challenges for clinicians and the research community. Intravascular ultrasound (IVUS) is commonly used in clinical practice for diagnosis and treatment decisions. However, due to IVUS limited...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706023/ https://www.ncbi.nlm.nih.gov/pubmed/33256759 http://dx.doi.org/10.1186/s12938-020-00832-w |
_version_ | 1783617067651432448 |
---|---|
author | Lv, Rui Maehara, Akiko Matsumura, Mitsuaki Wang, Liang Wang, Qingyu Zhang, Caining Guo, Xiaoya Samady, Habib Giddens, Don P. Zheng, Jie Mintz, Gary S. Tang, Dalin |
author_facet | Lv, Rui Maehara, Akiko Matsumura, Mitsuaki Wang, Liang Wang, Qingyu Zhang, Caining Guo, Xiaoya Samady, Habib Giddens, Don P. Zheng, Jie Mintz, Gary S. Tang, Dalin |
author_sort | Lv, Rui |
collection | PubMed |
description | BACKGROUND: Detecting coronary vulnerable plaques in vivo and assessing their vulnerability have been great challenges for clinicians and the research community. Intravascular ultrasound (IVUS) is commonly used in clinical practice for diagnosis and treatment decisions. However, due to IVUS limited resolution (about 150–200 µm), it is not sufficient to detect vulnerable plaques with a threshold cap thickness of 65 µm. Optical Coherence Tomography (OCT) has a resolution of 15–20 µm and can measure fibrous cap thickness more accurately. The aim of this study was to use OCT as the benchmark to obtain patient-specific coronary plaque cap thickness and evaluate the differences between OCT and IVUS fibrous cap quantifications. A cap index with integer values 0–4 was also introduced as a quantitative measure of plaque vulnerability to study plaque vulnerability. METHODS: Data from 10 patients (mean age: 70.4; m: 6; f: 4) with coronary heart disease who underwent IVUS, OCT, and angiography were collected at Cardiovascular Research Foundation (CRF) using approved protocol with informed consent obtained. 348 slices with lipid core and fibrous caps were selected for study. Convolutional Neural Network (CNN)-based and expert-based data segmentation were performed using established methods previously published. Cap thickness data were extracted to quantify differences between IVUS and OCT measurements. RESULTS: For the 348 slices analyzed, the mean value difference between OCT and IVUS cap thickness measurements was 1.83% (p = 0.031). However, mean value of point-to-point differences was 35.76%. Comparing minimum cap thickness for each plaque, the mean value of the 20 plaque IVUS-OCT differences was 44.46%, ranging from 2.36% to 91.15%. For cap index values assigned to the 348 slices, the disagreement between OCT and IVUS assignments was 25%. However, for the OCT cap index = 2 and 3 groups, the disagreement rates were 91% and 80%, respectively. Furthermore, the observation of cap index changes from baseline to follow-up indicated that IVUS results differed from OCT by 80%. CONCLUSIONS: These preliminary results demonstrated that there were significant differences between IVUS and OCT plaque cap thickness measurements. Large-scale patient studies are needed to confirm our findings. |
format | Online Article Text |
id | pubmed-7706023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77060232020-12-01 Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study Lv, Rui Maehara, Akiko Matsumura, Mitsuaki Wang, Liang Wang, Qingyu Zhang, Caining Guo, Xiaoya Samady, Habib Giddens, Don P. Zheng, Jie Mintz, Gary S. Tang, Dalin Biomed Eng Online Research BACKGROUND: Detecting coronary vulnerable plaques in vivo and assessing their vulnerability have been great challenges for clinicians and the research community. Intravascular ultrasound (IVUS) is commonly used in clinical practice for diagnosis and treatment decisions. However, due to IVUS limited resolution (about 150–200 µm), it is not sufficient to detect vulnerable plaques with a threshold cap thickness of 65 µm. Optical Coherence Tomography (OCT) has a resolution of 15–20 µm and can measure fibrous cap thickness more accurately. The aim of this study was to use OCT as the benchmark to obtain patient-specific coronary plaque cap thickness and evaluate the differences between OCT and IVUS fibrous cap quantifications. A cap index with integer values 0–4 was also introduced as a quantitative measure of plaque vulnerability to study plaque vulnerability. METHODS: Data from 10 patients (mean age: 70.4; m: 6; f: 4) with coronary heart disease who underwent IVUS, OCT, and angiography were collected at Cardiovascular Research Foundation (CRF) using approved protocol with informed consent obtained. 348 slices with lipid core and fibrous caps were selected for study. Convolutional Neural Network (CNN)-based and expert-based data segmentation were performed using established methods previously published. Cap thickness data were extracted to quantify differences between IVUS and OCT measurements. RESULTS: For the 348 slices analyzed, the mean value difference between OCT and IVUS cap thickness measurements was 1.83% (p = 0.031). However, mean value of point-to-point differences was 35.76%. Comparing minimum cap thickness for each plaque, the mean value of the 20 plaque IVUS-OCT differences was 44.46%, ranging from 2.36% to 91.15%. For cap index values assigned to the 348 slices, the disagreement between OCT and IVUS assignments was 25%. However, for the OCT cap index = 2 and 3 groups, the disagreement rates were 91% and 80%, respectively. Furthermore, the observation of cap index changes from baseline to follow-up indicated that IVUS results differed from OCT by 80%. CONCLUSIONS: These preliminary results demonstrated that there were significant differences between IVUS and OCT plaque cap thickness measurements. Large-scale patient studies are needed to confirm our findings. BioMed Central 2020-11-30 /pmc/articles/PMC7706023/ /pubmed/33256759 http://dx.doi.org/10.1186/s12938-020-00832-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lv, Rui Maehara, Akiko Matsumura, Mitsuaki Wang, Liang Wang, Qingyu Zhang, Caining Guo, Xiaoya Samady, Habib Giddens, Don P. Zheng, Jie Mintz, Gary S. Tang, Dalin Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study |
title | Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study |
title_full | Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study |
title_fullStr | Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study |
title_full_unstemmed | Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study |
title_short | Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study |
title_sort | using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706023/ https://www.ncbi.nlm.nih.gov/pubmed/33256759 http://dx.doi.org/10.1186/s12938-020-00832-w |
work_keys_str_mv | AT lvrui usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT maeharaakiko usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT matsumuramitsuaki usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT wangliang usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT wangqingyu usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT zhangcaining usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT guoxiaoya usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT samadyhabib usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT giddensdonp usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT zhengjie usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT mintzgarys usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy AT tangdalin usingopticalcoherencetomographyandintravascularultrasoundimagingtoquantifycoronaryplaquecapthicknessandvulnerabilityapilotstudy |