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iGIST—A Kinetic Bioassay for Pertussis Toxin Based on Its Effect on Inhibitory GPCR Signaling

[Image: see text] Detection of pertussis toxin (PTX) activity is instrumental for the development and manufacturing of pertussis vaccines. These quality and safety measures require thousands of mice annually. Here, we describe Interference in Gαi-mediated Signal Transduction (iGIST), an animal-free...

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Detalles Bibliográficos
Autores principales:	Paramonov, Valeriy M., Sahlgren, Cecilia, Rivero-Müller, Adolfo, Pulliainen, Arto T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706119/ https://www.ncbi.nlm.nih.gov/pubmed/33147407 http://dx.doi.org/10.1021/acssensors.0c01340

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