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CCTs as new biomarkers for the prognosis of head and neck squamous cancer

The chaperonin-containing T-complex protein 1 (CCT) subunits participate in diverse diseases. However, little is known about their expression and prognostic values in human head and neck squamous cancer (HNSC). This article aims to evaluate the effects of CCT subunits regarding their prognostic valu...

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Autores principales: Dong, Yanbo, Lu, Siyu, Wang, Zhenxiao, Liu, Liangfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706129/
https://www.ncbi.nlm.nih.gov/pubmed/33313411
http://dx.doi.org/10.1515/med-2020-0114
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author Dong, Yanbo
Lu, Siyu
Wang, Zhenxiao
Liu, Liangfa
author_facet Dong, Yanbo
Lu, Siyu
Wang, Zhenxiao
Liu, Liangfa
author_sort Dong, Yanbo
collection PubMed
description The chaperonin-containing T-complex protein 1 (CCT) subunits participate in diverse diseases. However, little is known about their expression and prognostic values in human head and neck squamous cancer (HNSC). This article aims to evaluate the effects of CCT subunits regarding their prognostic values for HNSC. We mined the transcriptional and survival data of CCTs in HNSC patients from online databases. A protein–protein interaction network was constructed and a functional enrichment analysis of target genes was performed. We observed that the mRNA expression levels of CCT1/2/3/4/5/6/7/8 were higher in HNSC tissues than in normal tissues. Survival analysis revealed that the high mRNA transcriptional levels of CCT3/4/5/6/7/8 were associated with a low overall survival. The expression levels of CCT4/7 were correlated with advanced tumor stage. And the overexpression of CCT4 was associated with higher N stage of patients. Validation of CCTs’ differential expression and prognostic values was achieved by the Human Protein Atlas and GEO datasets. Mechanistic exploration of CCT subunits by the functional enrichment analysis suggests that these genes may influence the HNSC prognosis by regulating PI3K-Akt and other pathways. This study implies that CCT3/4/6/7/8 are promising biomarkers for the prognosis of HNSC.
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spelling pubmed-77061292020-12-10 CCTs as new biomarkers for the prognosis of head and neck squamous cancer Dong, Yanbo Lu, Siyu Wang, Zhenxiao Liu, Liangfa Open Med (Wars) Research Article The chaperonin-containing T-complex protein 1 (CCT) subunits participate in diverse diseases. However, little is known about their expression and prognostic values in human head and neck squamous cancer (HNSC). This article aims to evaluate the effects of CCT subunits regarding their prognostic values for HNSC. We mined the transcriptional and survival data of CCTs in HNSC patients from online databases. A protein–protein interaction network was constructed and a functional enrichment analysis of target genes was performed. We observed that the mRNA expression levels of CCT1/2/3/4/5/6/7/8 were higher in HNSC tissues than in normal tissues. Survival analysis revealed that the high mRNA transcriptional levels of CCT3/4/5/6/7/8 were associated with a low overall survival. The expression levels of CCT4/7 were correlated with advanced tumor stage. And the overexpression of CCT4 was associated with higher N stage of patients. Validation of CCTs’ differential expression and prognostic values was achieved by the Human Protein Atlas and GEO datasets. Mechanistic exploration of CCT subunits by the functional enrichment analysis suggests that these genes may influence the HNSC prognosis by regulating PI3K-Akt and other pathways. This study implies that CCT3/4/6/7/8 are promising biomarkers for the prognosis of HNSC. De Gruyter 2020-07-13 /pmc/articles/PMC7706129/ /pubmed/33313411 http://dx.doi.org/10.1515/med-2020-0114 Text en © 2020 Yanbo Dong et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Dong, Yanbo
Lu, Siyu
Wang, Zhenxiao
Liu, Liangfa
CCTs as new biomarkers for the prognosis of head and neck squamous cancer
title CCTs as new biomarkers for the prognosis of head and neck squamous cancer
title_full CCTs as new biomarkers for the prognosis of head and neck squamous cancer
title_fullStr CCTs as new biomarkers for the prognosis of head and neck squamous cancer
title_full_unstemmed CCTs as new biomarkers for the prognosis of head and neck squamous cancer
title_short CCTs as new biomarkers for the prognosis of head and neck squamous cancer
title_sort ccts as new biomarkers for the prognosis of head and neck squamous cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706129/
https://www.ncbi.nlm.nih.gov/pubmed/33313411
http://dx.doi.org/10.1515/med-2020-0114
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