Hepatitis C: milestones from discovery to clinical cure

On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed fro...

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Autores principales: Hu, Wei, Zhang, Chao, Shi, Ji-Jing, Zhang, Ji-Yuan, Wang, Fu-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706235/
https://www.ncbi.nlm.nih.gov/pubmed/33261650
http://dx.doi.org/10.1186/s40779-020-00288-y
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author Hu, Wei
Zhang, Chao
Shi, Ji-Jing
Zhang, Ji-Yuan
Wang, Fu-Sheng
author_facet Hu, Wei
Zhang, Chao
Shi, Ji-Jing
Zhang, Ji-Yuan
Wang, Fu-Sheng
author_sort Hu, Wei
collection PubMed
description On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the “scientific journey” from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting antivirals. Further, we address the challenges and unmet issues in this field.
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spelling pubmed-77062352020-12-02 Hepatitis C: milestones from discovery to clinical cure Hu, Wei Zhang, Chao Shi, Ji-Jing Zhang, Ji-Yuan Wang, Fu-Sheng Mil Med Res Commentary On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the “scientific journey” from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting antivirals. Further, we address the challenges and unmet issues in this field. BioMed Central 2020-12-01 /pmc/articles/PMC7706235/ /pubmed/33261650 http://dx.doi.org/10.1186/s40779-020-00288-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Hu, Wei
Zhang, Chao
Shi, Ji-Jing
Zhang, Ji-Yuan
Wang, Fu-Sheng
Hepatitis C: milestones from discovery to clinical cure
title Hepatitis C: milestones from discovery to clinical cure
title_full Hepatitis C: milestones from discovery to clinical cure
title_fullStr Hepatitis C: milestones from discovery to clinical cure
title_full_unstemmed Hepatitis C: milestones from discovery to clinical cure
title_short Hepatitis C: milestones from discovery to clinical cure
title_sort hepatitis c: milestones from discovery to clinical cure
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706235/
https://www.ncbi.nlm.nih.gov/pubmed/33261650
http://dx.doi.org/10.1186/s40779-020-00288-y
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