Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

BACKGROUND: Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes with tumor-specific antibodies and T-cell checkpoint inhibitors by promoting m...

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Detalles Bibliográficos
Autores principales: Kuo, Tracy C., Chen, Amy, Harrabi, Ons, Sockolosky, Jonathan T., Zhang, Anli, Sangalang, Emma, Doyle, Laura V., Kauder, Steven E., Fontaine, Danielle, Bollini, Sangeetha, Han, Bora, Fu, Yang-Xin, Sim, Janet, Pons, Jaume, Wan, Hong I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706287/
https://www.ncbi.nlm.nih.gov/pubmed/33256806
http://dx.doi.org/10.1186/s13045-020-00989-w

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