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Senescence and the SASP: many therapeutic avenues
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and li...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706700/ https://www.ncbi.nlm.nih.gov/pubmed/33262144 http://dx.doi.org/10.1101/gad.343129.120 |
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author | Birch, Jodie Gil, Jesús |
author_facet | Birch, Jodie Gil, Jesús |
author_sort | Birch, Jodie |
collection | PubMed |
description | Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-related disorders. Thus, targeting senescent cells to delay aging and limit dysfunction, known as “senotherapy,” is gaining momentum. While drugs that selectively kill senescent cells, termed “senolytics” are a major focus, SASP-centered approaches are emerging as alternatives to target senescence-associated diseases. Here, we summarize the regulation and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentary or an alternative to current senolytic approaches. |
format | Online Article Text |
id | pubmed-7706700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77067002021-06-01 Senescence and the SASP: many therapeutic avenues Birch, Jodie Gil, Jesús Genes Dev Review Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-related disorders. Thus, targeting senescent cells to delay aging and limit dysfunction, known as “senotherapy,” is gaining momentum. While drugs that selectively kill senescent cells, termed “senolytics” are a major focus, SASP-centered approaches are emerging as alternatives to target senescence-associated diseases. Here, we summarize the regulation and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentary or an alternative to current senolytic approaches. Cold Spring Harbor Laboratory Press 2020-12-01 /pmc/articles/PMC7706700/ /pubmed/33262144 http://dx.doi.org/10.1101/gad.343129.120 Text en © 2020 Birch and Gil; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Birch, Jodie Gil, Jesús Senescence and the SASP: many therapeutic avenues |
title | Senescence and the SASP: many therapeutic avenues |
title_full | Senescence and the SASP: many therapeutic avenues |
title_fullStr | Senescence and the SASP: many therapeutic avenues |
title_full_unstemmed | Senescence and the SASP: many therapeutic avenues |
title_short | Senescence and the SASP: many therapeutic avenues |
title_sort | senescence and the sasp: many therapeutic avenues |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706700/ https://www.ncbi.nlm.nih.gov/pubmed/33262144 http://dx.doi.org/10.1101/gad.343129.120 |
work_keys_str_mv | AT birchjodie senescenceandthesaspmanytherapeuticavenues AT giljesus senescenceandthesaspmanytherapeuticavenues |