The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas

Circadian clocks in pancreatic islets participate in the regulation of glucose homeostasis. Here we examined the role of these timekeepers in β-cell regeneration after the massive ablation of β cells by doxycycline-induced expression of diphtheria toxin A (DTA) in Insulin-rtTA/TET-DTA mice. Since we...

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Detalles Bibliográficos
Autores principales: Petrenko, Volodymyr, Stolovich-Rain, Miri, Vandereycken, Bart, Giovannoni, Laurianne, Storch, Kai-Florian, Dor, Yuval, Chera, Simona, Dibner, Charna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706703/
https://www.ncbi.nlm.nih.gov/pubmed/33184223
http://dx.doi.org/10.1101/gad.343137.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706703/
https://www.ncbi.nlm.nih.gov/pubmed/33184223
http://dx.doi.org/10.1101/gad.343137.120

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