Cargando…
Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region
Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful approach to link seemingly unrelated cases, and large-scale sequencing surveillance can inform on critical epidemiological parameters....
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706732/ https://www.ncbi.nlm.nih.gov/pubmed/33093069 http://dx.doi.org/10.1101/gr.266676.120 |
| _version_ | 1783617210922565632 |
|---|---|
| author | Maurano, Matthew T. Ramaswami, Sitharam Zappile, Paul Dimartino, Dacia Boytard, Ludovic Ribeiro-dos-Santos, André M. Vulpescu, Nicholas A. Westby, Gael Shen, Guomiao Feng, Xiaojun Hogan, Megan S. Ragonnet-Cronin, Manon Geidelberg, Lily Marier, Christian Meyn, Peter Zhang, Yutong Cadley, John Ordoñez, Raquel Luther, Raven Huang, Emily Guzman, Emily Arguelles-Grande, Carolina Argyropoulos, Kimon V. Black, Margaret Serrano, Antonio Call, Melissa E. Kim, Min Jae Belovarac, Brendan Gindin, Tatyana Lytle, Andrew Pinnell, Jared Vougiouklakis, Theodore Chen, John Lin, Lawrence H. Rapkiewicz, Amy Raabe, Vanessa Samanovic, Marie I. Jour, George Osman, Iman Aguero-Rosenfeld, Maria Mulligan, Mark J. Volz, Erik M. Cotzia, Paolo Snuderl, Matija Heguy, Adriana |
| author_facet | Maurano, Matthew T. Ramaswami, Sitharam Zappile, Paul Dimartino, Dacia Boytard, Ludovic Ribeiro-dos-Santos, André M. Vulpescu, Nicholas A. Westby, Gael Shen, Guomiao Feng, Xiaojun Hogan, Megan S. Ragonnet-Cronin, Manon Geidelberg, Lily Marier, Christian Meyn, Peter Zhang, Yutong Cadley, John Ordoñez, Raquel Luther, Raven Huang, Emily Guzman, Emily Arguelles-Grande, Carolina Argyropoulos, Kimon V. Black, Margaret Serrano, Antonio Call, Melissa E. Kim, Min Jae Belovarac, Brendan Gindin, Tatyana Lytle, Andrew Pinnell, Jared Vougiouklakis, Theodore Chen, John Lin, Lawrence H. Rapkiewicz, Amy Raabe, Vanessa Samanovic, Marie I. Jour, George Osman, Iman Aguero-Rosenfeld, Maria Mulligan, Mark J. Volz, Erik M. Cotzia, Paolo Snuderl, Matija Heguy, Adriana |
| author_sort | Maurano, Matthew T. |
| collection | PubMed |
| description | Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful approach to link seemingly unrelated cases, and large-scale sequencing surveillance can inform on critical epidemiological parameters. Here, we report the analysis of 864 SARS-CoV-2 sequences from cases in the New York City metropolitan area during the COVID-19 outbreak in spring 2020. The majority of cases had no recent travel history or known exposure, and genetically linked cases were spread throughout the region. Comparison to global viral sequences showed that early transmission was most linked to cases from Europe. Our data are consistent with numerous seeds from multiple sources and a prolonged period of unrecognized community spreading. This work highlights the complementary role of genomic surveillance in addition to traditional epidemiological indicators. |
| format | Online Article Text |
| id | pubmed-7706732 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Cold Spring Harbor Laboratory Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77067322020-12-09 Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region Maurano, Matthew T. Ramaswami, Sitharam Zappile, Paul Dimartino, Dacia Boytard, Ludovic Ribeiro-dos-Santos, André M. Vulpescu, Nicholas A. Westby, Gael Shen, Guomiao Feng, Xiaojun Hogan, Megan S. Ragonnet-Cronin, Manon Geidelberg, Lily Marier, Christian Meyn, Peter Zhang, Yutong Cadley, John Ordoñez, Raquel Luther, Raven Huang, Emily Guzman, Emily Arguelles-Grande, Carolina Argyropoulos, Kimon V. Black, Margaret Serrano, Antonio Call, Melissa E. Kim, Min Jae Belovarac, Brendan Gindin, Tatyana Lytle, Andrew Pinnell, Jared Vougiouklakis, Theodore Chen, John Lin, Lawrence H. Rapkiewicz, Amy Raabe, Vanessa Samanovic, Marie I. Jour, George Osman, Iman Aguero-Rosenfeld, Maria Mulligan, Mark J. Volz, Erik M. Cotzia, Paolo Snuderl, Matija Heguy, Adriana Genome Res Research Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful approach to link seemingly unrelated cases, and large-scale sequencing surveillance can inform on critical epidemiological parameters. Here, we report the analysis of 864 SARS-CoV-2 sequences from cases in the New York City metropolitan area during the COVID-19 outbreak in spring 2020. The majority of cases had no recent travel history or known exposure, and genetically linked cases were spread throughout the region. Comparison to global viral sequences showed that early transmission was most linked to cases from Europe. Our data are consistent with numerous seeds from multiple sources and a prolonged period of unrecognized community spreading. This work highlights the complementary role of genomic surveillance in addition to traditional epidemiological indicators. Cold Spring Harbor Laboratory Press 2020-12 /pmc/articles/PMC7706732/ /pubmed/33093069 http://dx.doi.org/10.1101/gr.266676.120 Text en © 2020 Maurano et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
| spellingShingle | Research Maurano, Matthew T. Ramaswami, Sitharam Zappile, Paul Dimartino, Dacia Boytard, Ludovic Ribeiro-dos-Santos, André M. Vulpescu, Nicholas A. Westby, Gael Shen, Guomiao Feng, Xiaojun Hogan, Megan S. Ragonnet-Cronin, Manon Geidelberg, Lily Marier, Christian Meyn, Peter Zhang, Yutong Cadley, John Ordoñez, Raquel Luther, Raven Huang, Emily Guzman, Emily Arguelles-Grande, Carolina Argyropoulos, Kimon V. Black, Margaret Serrano, Antonio Call, Melissa E. Kim, Min Jae Belovarac, Brendan Gindin, Tatyana Lytle, Andrew Pinnell, Jared Vougiouklakis, Theodore Chen, John Lin, Lawrence H. Rapkiewicz, Amy Raabe, Vanessa Samanovic, Marie I. Jour, George Osman, Iman Aguero-Rosenfeld, Maria Mulligan, Mark J. Volz, Erik M. Cotzia, Paolo Snuderl, Matija Heguy, Adriana Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region |
| title | Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region |
| title_full | Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region |
| title_fullStr | Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region |
| title_full_unstemmed | Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region |
| title_short | Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region |
| title_sort | sequencing identifies multiple early introductions of sars-cov-2 to the new york city region |
| topic | Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706732/ https://www.ncbi.nlm.nih.gov/pubmed/33093069 http://dx.doi.org/10.1101/gr.266676.120 |
| work_keys_str_mv | AT mauranomatthewt sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT ramaswamisitharam sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT zappilepaul sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT dimartinodacia sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT boytardludovic sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT ribeirodossantosandrem sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT vulpescunicholasa sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT westbygael sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT shenguomiao sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT fengxiaojun sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT hoganmegans sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT ragonnetcroninmanon sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT geidelberglily sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT marierchristian sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT meynpeter sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT zhangyutong sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT cadleyjohn sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT ordonezraquel sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT lutherraven sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT huangemily sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT guzmanemily sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT arguellesgrandecarolina sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT argyropouloskimonv sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT blackmargaret sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT serranoantonio sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT callmelissae sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT kimminjae sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT belovaracbrendan sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT gindintatyana sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT lytleandrew sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT pinnelljared sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT vougiouklakistheodore sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT chenjohn sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT linlawrenceh sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT rapkiewiczamy sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT raabevanessa sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT samanovicmariei sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT jourgeorge sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT osmaniman sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT aguerorosenfeldmaria sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT mulliganmarkj sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT volzerikm sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT cotziapaolo sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT snuderlmatija sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion AT heguyadriana sequencingidentifiesmultipleearlyintroductionsofsarscov2tothenewyorkcityregion |