Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural m...

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Autores principales: Lau, Susanna K.P., Wong, Antonio C.P., Luk, Hayes K.H., Li, Kenneth S.M., Fung, Joshua, He, Zirong, Cheng, Flora K.K., Chan, Tony T.Y., Chu, Stella, Aw-Yong, Kam Leng, Lau, Terrence C.K., Fung, Kitty S.C., Woo, Patrick C.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706959/
https://www.ncbi.nlm.nih.gov/pubmed/32730733
http://dx.doi.org/10.3201/eid2612.202308
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author Lau, Susanna K.P.
Wong, Antonio C.P.
Luk, Hayes K.H.
Li, Kenneth S.M.
Fung, Joshua
He, Zirong
Cheng, Flora K.K.
Chan, Tony T.Y.
Chu, Stella
Aw-Yong, Kam Leng
Lau, Terrence C.K.
Fung, Kitty S.C.
Woo, Patrick C.Y.
author_facet Lau, Susanna K.P.
Wong, Antonio C.P.
Luk, Hayes K.H.
Li, Kenneth S.M.
Fung, Joshua
He, Zirong
Cheng, Flora K.K.
Chan, Tony T.Y.
Chu, Stella
Aw-Yong, Kam Leng
Lau, Terrence C.K.
Fung, Kitty S.C.
Woo, Patrick C.Y.
author_sort Lau, Susanna K.P.
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
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spelling pubmed-77069592020-12-08 Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells Lau, Susanna K.P. Wong, Antonio C.P. Luk, Hayes K.H. Li, Kenneth S.M. Fung, Joshua He, Zirong Cheng, Flora K.K. Chan, Tony T.Y. Chu, Stella Aw-Yong, Kam Leng Lau, Terrence C.K. Fung, Kitty S.C. Woo, Patrick C.Y. Emerg Infect Dis Dispatch Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism. Centers for Disease Control and Prevention 2020-12 /pmc/articles/PMC7706959/ /pubmed/32730733 http://dx.doi.org/10.3201/eid2612.202308 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Lau, Susanna K.P.
Wong, Antonio C.P.
Luk, Hayes K.H.
Li, Kenneth S.M.
Fung, Joshua
He, Zirong
Cheng, Flora K.K.
Chan, Tony T.Y.
Chu, Stella
Aw-Yong, Kam Leng
Lau, Terrence C.K.
Fung, Kitty S.C.
Woo, Patrick C.Y.
Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
title Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
title_full Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
title_fullStr Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
title_full_unstemmed Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
title_short Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
title_sort differential tropism of sars-cov and sars-cov-2 in bat cells
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706959/
https://www.ncbi.nlm.nih.gov/pubmed/32730733
http://dx.doi.org/10.3201/eid2612.202308
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