HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS is limited. Because autoreactive CD4(+) T cells and B cells as antigen-presenting cells are involved in MS pathogenesis, we characterized the immunopeptidomes of...

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Detalles Bibliográficos
Autores principales: Wang, Jian, Jelcic, Ivan, Mühlenbruch, Lena, Haunerdinger, Veronika, Toussaint, Nora C., Zhao, Yingdong, Cruciani, Carolina, Faigle, Wolfgang, Naghavian, Reza, Foege, Magdalena, Binder, Thomas M.C., Eiermann, Thomas, Opitz, Lennart, Fuentes-Font, Laura, Reynolds, Richard, Kwok, William W., Nguyen, Julie T., Lee, Jar-How, Lutterotti, Andreas, Münz, Christian, Rammensee, Hans-Georg, Hauri-Hohl, Mathias, Sospedra, Mireia, Stevanovic, Stefan, Martin, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707104/
https://www.ncbi.nlm.nih.gov/pubmed/33091337
http://dx.doi.org/10.1016/j.cell.2020.09.054

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