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The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation

The hippocampal-entorhinal system is important for spatial and relational memory tasks. We formally link these domains, provide a mechanistic understanding of the hippocampal role in generalization, and offer unifying principles underlying many entorhinal and hippocampal cell types. We propose media...

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Detalles Bibliográficos
Autores principales: Whittington, James C.R., Muller, Timothy H., Mark, Shirley, Chen, Guifen, Barry, Caswell, Burgess, Neil, Behrens, Timothy E.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707106/
https://www.ncbi.nlm.nih.gov/pubmed/33181068
http://dx.doi.org/10.1016/j.cell.2020.10.024
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author Whittington, James C.R.
Muller, Timothy H.
Mark, Shirley
Chen, Guifen
Barry, Caswell
Burgess, Neil
Behrens, Timothy E.J.
author_facet Whittington, James C.R.
Muller, Timothy H.
Mark, Shirley
Chen, Guifen
Barry, Caswell
Burgess, Neil
Behrens, Timothy E.J.
author_sort Whittington, James C.R.
collection PubMed
description The hippocampal-entorhinal system is important for spatial and relational memory tasks. We formally link these domains, provide a mechanistic understanding of the hippocampal role in generalization, and offer unifying principles underlying many entorhinal and hippocampal cell types. We propose medial entorhinal cells form a basis describing structural knowledge, and hippocampal cells link this basis with sensory representations. Adopting these principles, we introduce the Tolman-Eichenbaum machine (TEM). After learning, TEM entorhinal cells display diverse properties resembling apparently bespoke spatial responses, such as grid, band, border, and object-vector cells. TEM hippocampal cells include place and landmark cells that remap between environments. Crucially, TEM also aligns with empirically recorded representations in complex non-spatial tasks. TEM also generates predictions that hippocampal remapping is not random as previously believed; rather, structural knowledge is preserved across environments. We confirm this structural transfer over remapping in simultaneously recorded place and grid cells.
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spelling pubmed-77071062020-12-08 The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation Whittington, James C.R. Muller, Timothy H. Mark, Shirley Chen, Guifen Barry, Caswell Burgess, Neil Behrens, Timothy E.J. Cell Article The hippocampal-entorhinal system is important for spatial and relational memory tasks. We formally link these domains, provide a mechanistic understanding of the hippocampal role in generalization, and offer unifying principles underlying many entorhinal and hippocampal cell types. We propose medial entorhinal cells form a basis describing structural knowledge, and hippocampal cells link this basis with sensory representations. Adopting these principles, we introduce the Tolman-Eichenbaum machine (TEM). After learning, TEM entorhinal cells display diverse properties resembling apparently bespoke spatial responses, such as grid, band, border, and object-vector cells. TEM hippocampal cells include place and landmark cells that remap between environments. Crucially, TEM also aligns with empirically recorded representations in complex non-spatial tasks. TEM also generates predictions that hippocampal remapping is not random as previously believed; rather, structural knowledge is preserved across environments. We confirm this structural transfer over remapping in simultaneously recorded place and grid cells. Cell Press 2020-11-25 /pmc/articles/PMC7707106/ /pubmed/33181068 http://dx.doi.org/10.1016/j.cell.2020.10.024 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Whittington, James C.R.
Muller, Timothy H.
Mark, Shirley
Chen, Guifen
Barry, Caswell
Burgess, Neil
Behrens, Timothy E.J.
The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation
title The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation
title_full The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation
title_fullStr The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation
title_full_unstemmed The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation
title_short The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation
title_sort tolman-eichenbaum machine: unifying space and relational memory through generalization in the hippocampal formation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707106/
https://www.ncbi.nlm.nih.gov/pubmed/33181068
http://dx.doi.org/10.1016/j.cell.2020.10.024
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