Severe Pancytopenia Induced by Valproic Acid

Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mc...

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Detalles Bibliográficos
Autores principales: Wahba, Andrew, Bergez, Emmalee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707128/
https://www.ncbi.nlm.nih.gov/pubmed/33269170
http://dx.doi.org/10.7759/cureus.11252
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author Wahba, Andrew
Bergez, Emmalee
author_facet Wahba, Andrew
Bergez, Emmalee
author_sort Wahba, Andrew
collection PubMed
description Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mcg/mL. Reported cases indicate an increased incidence of hematologic toxicity; however, evidence for management is limited. We report a case of bone marrow suppression induced by a high dose of valproic acid in a 10-year-old male.
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spelling pubmed-77071282020-12-01 Severe Pancytopenia Induced by Valproic Acid Wahba, Andrew Bergez, Emmalee Cureus Neurology Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mcg/mL. Reported cases indicate an increased incidence of hematologic toxicity; however, evidence for management is limited. We report a case of bone marrow suppression induced by a high dose of valproic acid in a 10-year-old male. Cureus 2020-10-30 /pmc/articles/PMC7707128/ /pubmed/33269170 http://dx.doi.org/10.7759/cureus.11252 Text en Copyright © 2020, Wahba et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Wahba, Andrew
Bergez, Emmalee
Severe Pancytopenia Induced by Valproic Acid
title Severe Pancytopenia Induced by Valproic Acid
title_full Severe Pancytopenia Induced by Valproic Acid
title_fullStr Severe Pancytopenia Induced by Valproic Acid
title_full_unstemmed Severe Pancytopenia Induced by Valproic Acid
title_short Severe Pancytopenia Induced by Valproic Acid
title_sort severe pancytopenia induced by valproic acid
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707128/
https://www.ncbi.nlm.nih.gov/pubmed/33269170
http://dx.doi.org/10.7759/cureus.11252
work_keys_str_mv AT wahbaandrew severepancytopeniainducedbyvalproicacid
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