Severe Pancytopenia Induced by Valproic Acid
Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707128/ https://www.ncbi.nlm.nih.gov/pubmed/33269170 http://dx.doi.org/10.7759/cureus.11252 |
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author | Wahba, Andrew Bergez, Emmalee |
author_facet | Wahba, Andrew Bergez, Emmalee |
author_sort | Wahba, Andrew |
collection | PubMed |
description | Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mcg/mL. Reported cases indicate an increased incidence of hematologic toxicity; however, evidence for management is limited. We report a case of bone marrow suppression induced by a high dose of valproic acid in a 10-year-old male. |
format | Online Article Text |
id | pubmed-7707128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-77071282020-12-01 Severe Pancytopenia Induced by Valproic Acid Wahba, Andrew Bergez, Emmalee Cureus Neurology Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mcg/mL. Reported cases indicate an increased incidence of hematologic toxicity; however, evidence for management is limited. We report a case of bone marrow suppression induced by a high dose of valproic acid in a 10-year-old male. Cureus 2020-10-30 /pmc/articles/PMC7707128/ /pubmed/33269170 http://dx.doi.org/10.7759/cureus.11252 Text en Copyright © 2020, Wahba et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurology Wahba, Andrew Bergez, Emmalee Severe Pancytopenia Induced by Valproic Acid |
title | Severe Pancytopenia Induced by Valproic Acid |
title_full | Severe Pancytopenia Induced by Valproic Acid |
title_fullStr | Severe Pancytopenia Induced by Valproic Acid |
title_full_unstemmed | Severe Pancytopenia Induced by Valproic Acid |
title_short | Severe Pancytopenia Induced by Valproic Acid |
title_sort | severe pancytopenia induced by valproic acid |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707128/ https://www.ncbi.nlm.nih.gov/pubmed/33269170 http://dx.doi.org/10.7759/cureus.11252 |
work_keys_str_mv | AT wahbaandrew severepancytopeniainducedbyvalproicacid AT bergezemmalee severepancytopeniainducedbyvalproicacid |