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The impact of different negative training data on regulatory sequence predictions

Regulatory regions, like promoters and enhancers, cover an estimated 5–15% of the human genome. Changes to these sequences are thought to underlie much of human phenotypic variation and a substantial proportion of genetic causes of disease. However, our understanding of their functional encoding in...

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Detalles Bibliográficos
Autores principales: Krützfeldt, Louisa-Marie, Schubach, Max, Kircher, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707526/
https://www.ncbi.nlm.nih.gov/pubmed/33259518
http://dx.doi.org/10.1371/journal.pone.0237412