A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins

[Image: see text] A phenotypic high-throughput screen identified a benzamide small molecule with activity against small cell lung cancer cells. A “clickable” benzamide probe was designed that irreversibly bound a single 50 kDa cellular protein, identified by mass spectrometry as β-tubulin. Moreover,...

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Detalles Bibliográficos
Autores principales: Povedano, Juan Manuel, Rallabandi, Rameshu, Bai, Xin, Ye, Xuecheng, Liou, Joel, Chen, Hong, Kim, Jiwoong, Xie, Yang, Posner, Bruce, Rice, Luke, De Brabander, Jef K., McFadden, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707623/
https://www.ncbi.nlm.nih.gov/pubmed/33180487
http://dx.doi.org/10.1021/acs.jmedchem.0c01482

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