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Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes

The mechanisms underlying resistance of the Chagas disease parasite, Trypanosoma cruzi, to current therapies are not well understood, including the role of metabolic heterogeneity. We found that limiting exogenous glutamine protects actively dividing amastigotes from ergosterol biosynthesis inhibito...

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Detalles Bibliográficos
Autores principales:	Dumoulin, Peter C, Vollrath, Joshua, Tomko, Sheena Shah, Wang, Jennifer X, Burleigh, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707839/ https://www.ncbi.nlm.nih.gov/pubmed/33258448 http://dx.doi.org/10.7554/eLife.60226

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