Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin's Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study

BACKGROUND: Hodgkin's lymphoma (HL) constitutes 10%–20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%). Recently, interest has increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors. We aimed to s...

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Detalles Bibliográficos
Autores principales: Lee, Jae Min, Choi, Jung Yoon, Hong, Kyung Taek, Kang, Hyoung Jin, Shin, Hee Young, Baek, Hee Jo, Kook, Hoon, Kim, Seongkoo, Lee, Jae Wook, Chung, Nack-Gyun, Cho, Bin, Cho, Seok-Goo, Park, Kyung Mi, Yang, Eu Jeen, Lim, Young Tak, Suh, Jin Kyung, Kang, Sung Han, Kim, Hyery, Koh, Kyung-Nam, Im, Ho Joon, Seo, Jong Jin, Cho, Hee Won, Ju, Hee Young, Lee, Ji Won, Yoo, Keon Hee, Sung, Ki Woong, Koo, Hong Hoe, Park, Kyung Duk, Hah, Jeong Ok, Kim, Min Kyoung, Han, Jung Woo, Hahn, Seung Min, Lyu, Chuhl Joo, Shim, Ye Jee, Kim, Heung Sik, Do, Young Rok, Yoo, Jae Won, Lim, Yeon Jung, Jeon, In-Sang, Chueh, Hee won, Oh, Sung Yong, Choi, Hyoung Soo, Park, Jun Eun, Lee, Jun Ah, Park, Hyeon Jin, Park, Byung-Kiu, Kim, Soon Ki, Lim, Jae Young, Park, Eun Sil, Park, Sang Kyu, Choi, Eun Jin, Choi, Young Bae, Yoon, Jong Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707923/
https://www.ncbi.nlm.nih.gov/pubmed/33258329
http://dx.doi.org/10.3346/jkms.2020.35.e393
Descripción
Sumario:BACKGROUND: Hodgkin's lymphoma (HL) constitutes 10%–20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%). Recently, interest has increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors. We aimed to study the epidemiologic features and therapeutic outcomes of HL in children, adolescents, and young adults in Korea. METHODS: We performed a multicenter, retrospective study of 224 patients aged < 25 years diagnosed with HL at 22 participating institutes in Korea from January 2007 to August 2016. RESULTS: A higher percentage of males was diagnosed at a younger age. Nodular sclerosis histopathological HL subtype was most common, followed by mixed cellularity subtype. Eighty-one (36.2%), 101 (45.1%), and 42 (18.8%) patients were classified into low, intermediate, and high-risk groups, respectively. Doxorubicin, bleomycin, vinblastine, dacarbazine was the most common protocol (n = 102, 45.5%). Event-free survival rate was 86.0% ± 2.4%, while five-year overall survival (OS) rate was 96.1% ± 1.4%: 98.7% ± 1.3%, 97.7% ± 1.6%, and 86.5% ± 5.6% in the low, intermediate, and high-risk groups, respectively (P = 0.021). Five-year OS was worse in patients with B-symptoms, stage IV disease, high-risk, splenic involvement, extra-nodal lymphoma, and elevated lactate dehydrogenase level. In multivariate analysis, B-symptoms and extra-nodal involvement were prognostic factors for poor OS. Late complications of endocrine disorders and secondary malignancy were observed in 17 and 6 patients, respectively. CONCLUSION: This is the first study on the epidemiology and treatment outcomes of HL in children, adolescents, and young adults in Korea. Future prospective studies are indicated to develop therapies that minimize treatment toxicity while maximizing cure rates in children, adolescents, and young adults with HL.

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