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Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel

This study compared the anthelminthic effects of three different brands of praziquantel being used in Sudan against Schistosoma haematobium (S. haematobium) infection. We enrolled 1,286 schoolchildren from six primary schools and examined their urine samples for eggs of S. haematobium at the baselin...

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Autores principales: Jin, Yan, Cha, Seungman, Lee, Jinmoo, Elhag, Mousab Siddig, Hong, Sung-Tae, Lee, Young-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707925/
https://www.ncbi.nlm.nih.gov/pubmed/33258330
http://dx.doi.org/10.3346/jkms.2020.35.e394
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author Jin, Yan
Cha, Seungman
Lee, Jinmoo
Elhag, Mousab Siddig
Hong, Sung-Tae
Lee, Young-Ha
author_facet Jin, Yan
Cha, Seungman
Lee, Jinmoo
Elhag, Mousab Siddig
Hong, Sung-Tae
Lee, Young-Ha
author_sort Jin, Yan
collection PubMed
description This study compared the anthelminthic effects of three different brands of praziquantel being used in Sudan against Schistosoma haematobium (S. haematobium) infection. We enrolled 1,286 schoolchildren from six primary schools and examined their urine samples for eggs of S. haematobium at the baseline survey and follow-up two weeks after administering the medication. The schoolchildren were divided into three groups based on the three brands of praziquantel (different material production), with two school children for one brand. The overall baseline prevalence of S. haematobium infection was 15.5%. Two weeks after treatment with brands A, B, and C of praziquantel, cure rates were 87.1%, 82.4% and 83.8% respectively, and the egg-reduction rates were 69.0%, 81.0% and 70.6% respectively. There was no statistically significant difference in cure rates and egg-reduction rates between the three brands. We conclude that the three different commercial brands of praziquantel used in Sudan have similar anthelminthic effects on S. haematobium.
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spelling pubmed-77079252020-12-08 Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel Jin, Yan Cha, Seungman Lee, Jinmoo Elhag, Mousab Siddig Hong, Sung-Tae Lee, Young-Ha J Korean Med Sci Brief Communication This study compared the anthelminthic effects of three different brands of praziquantel being used in Sudan against Schistosoma haematobium (S. haematobium) infection. We enrolled 1,286 schoolchildren from six primary schools and examined their urine samples for eggs of S. haematobium at the baseline survey and follow-up two weeks after administering the medication. The schoolchildren were divided into three groups based on the three brands of praziquantel (different material production), with two school children for one brand. The overall baseline prevalence of S. haematobium infection was 15.5%. Two weeks after treatment with brands A, B, and C of praziquantel, cure rates were 87.1%, 82.4% and 83.8% respectively, and the egg-reduction rates were 69.0%, 81.0% and 70.6% respectively. There was no statistically significant difference in cure rates and egg-reduction rates between the three brands. We conclude that the three different commercial brands of praziquantel used in Sudan have similar anthelminthic effects on S. haematobium. The Korean Academy of Medical Sciences 2020-11-06 /pmc/articles/PMC7707925/ /pubmed/33258330 http://dx.doi.org/10.3346/jkms.2020.35.e394 Text en © 2020 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Jin, Yan
Cha, Seungman
Lee, Jinmoo
Elhag, Mousab Siddig
Hong, Sung-Tae
Lee, Young-Ha
Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel
title Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel
title_full Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel
title_fullStr Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel
title_full_unstemmed Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel
title_short Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel
title_sort parasitological observation in schoolchildren with urogenital schistosomiasis following treatment with three different brands of praziquantel
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707925/
https://www.ncbi.nlm.nih.gov/pubmed/33258330
http://dx.doi.org/10.3346/jkms.2020.35.e394
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