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The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. METHODS:...

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Autores principales: Xu, Chongwen, Han, Peng, Ren, Wanli, Dai, Hao, Bai, Yanxia, Shen, Zhen, Li, Baiya, Shao, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707933/
https://www.ncbi.nlm.nih.gov/pubmed/33299861
http://dx.doi.org/10.1155/2020/2329196
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author Xu, Chongwen
Han, Peng
Ren, Wanli
Dai, Hao
Bai, Yanxia
Shen, Zhen
Li, Baiya
Shao, Yuan
author_facet Xu, Chongwen
Han, Peng
Ren, Wanli
Dai, Hao
Bai, Yanxia
Shen, Zhen
Li, Baiya
Shao, Yuan
author_sort Xu, Chongwen
collection PubMed
description PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. METHODS: We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. RESULTS: Our study revealed that rs7336610 (OR 1.77, 95%CI = 1.09‐2.86, and p = 0.021) and rs1428 (OR 1.73, 95%CI = 1.07‐2.81, and p = 0.025) are strongly associated with increased susceptibility to HNSCC in men. Besides, rs17735387 played a crucial protective role in stage III/IV HNSCC patients (OR 0.34, 95%CI = 0.12‐0.95, and p = 0.040) compared with stage I/II. CONCLUSION: Our study firstly indicated that MIR17HG polymorphisms are significantly associated with HNSCC susceptibility, which suggests that MIR17HG has a potential role in the occurrence of HNSCC.
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spelling pubmed-77079332020-12-08 The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population Xu, Chongwen Han, Peng Ren, Wanli Dai, Hao Bai, Yanxia Shen, Zhen Li, Baiya Shao, Yuan Biomed Res Int Research Article PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. METHODS: We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. RESULTS: Our study revealed that rs7336610 (OR 1.77, 95%CI = 1.09‐2.86, and p = 0.021) and rs1428 (OR 1.73, 95%CI = 1.07‐2.81, and p = 0.025) are strongly associated with increased susceptibility to HNSCC in men. Besides, rs17735387 played a crucial protective role in stage III/IV HNSCC patients (OR 0.34, 95%CI = 0.12‐0.95, and p = 0.040) compared with stage I/II. CONCLUSION: Our study firstly indicated that MIR17HG polymorphisms are significantly associated with HNSCC susceptibility, which suggests that MIR17HG has a potential role in the occurrence of HNSCC. Hindawi 2020-11-24 /pmc/articles/PMC7707933/ /pubmed/33299861 http://dx.doi.org/10.1155/2020/2329196 Text en Copyright © 2020 Chongwen Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xu, Chongwen
Han, Peng
Ren, Wanli
Dai, Hao
Bai, Yanxia
Shen, Zhen
Li, Baiya
Shao, Yuan
The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
title The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
title_full The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
title_fullStr The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
title_full_unstemmed The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
title_short The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
title_sort genetic polymorphisms in the mir17hg gene are associated with the risk of head and neck squamous cell carcinoma in the chinese han population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707933/
https://www.ncbi.nlm.nih.gov/pubmed/33299861
http://dx.doi.org/10.1155/2020/2329196
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