Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote Kras/Lkb1/Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion

Nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial transcription factor for cell adaptation and defense against oxidative stress. NRF2 activation confers Kras/Lkb1/Keap1 (KLK) mutant tumor cells with greater resistance to oxidative insults. We previously reported that SUMOylation at lys...

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Detalles Bibliográficos
Autores principales: Xu, Jiaqian, Guo, Haoyan, Xing, Zhengcao, Zhang, Wenlong, He, Jianli, Cheng, Jinke, Cai, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708001/
https://www.ncbi.nlm.nih.gov/pubmed/33299528
http://dx.doi.org/10.1155/2020/6240125

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