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Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress

The highly conserved Tof1/Timeless proteins minimise replication stress and promote normal DNA replication. They are required to mediate the DNA replication checkpoint (DRC), the stable pausing of forks at protein fork blocks, the coupling of DNA helicase and polymerase functions during replication...

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Detalles Bibliográficos
Autores principales:	Westhorpe, Rose, Keszthelyi, Andrea, Minchell, Nicola E, Jones, David, Baxter, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708041/ https://www.ncbi.nlm.nih.gov/pubmed/33166393 http://dx.doi.org/10.1093/nar/gkaa963

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