Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance

We have previously reported that p53 decelerates nascent DNA elongation in complex with the translesion synthesis (TLS) polymerase ι (POLι) which triggers a homology-directed DNA damage tolerance (DDT) pathway to bypass obstacles during DNA replication. Here, we demonstrate that this DDT pathway rel...

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Detalles Bibliográficos
Autores principales: Biber, Stephanie, Pospiech, Helmut, Gottifredi, Vanesa, Wiesmüller, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708082/
https://www.ncbi.nlm.nih.gov/pubmed/33166398
http://dx.doi.org/10.1093/nar/gkaa974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708082/
https://www.ncbi.nlm.nih.gov/pubmed/33166398
http://dx.doi.org/10.1093/nar/gkaa974

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