ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation

BACKGROUND: Bone destruction is a hallmark of multiple myeloma (MM). It has been reported that proteasome inhibitors (PIs) can reduce bone resorption and increase bone formation in MM patients, but the underlying mechanisms remain unclear. METHODS: Mesenchymal stem cells (MSCs) were treated with var...

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Detalles Bibliográficos
Autores principales: Zhang, Dan, De Veirman, Kim, Fan, Rong, Jian, Qiang, Zhang, Yuchen, Lei, Li, Evans, Holly, Wang, Yanmeng, Lei, Lei, Wang, Baiyan, Williamson, Ramone A., Chantry, Andrew, He, Pengcheng, Li, Ang, De Raeve, Hendrik, Vanderkerken, Karin, He, Aili, Hu, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708206/
https://www.ncbi.nlm.nih.gov/pubmed/33256835
http://dx.doi.org/10.1186/s13287-020-02037-3

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