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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study

BACKGROUND: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. METHODS: Data on 2304 women from an ongoing cohort comprising 40,000 women from Ch...

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Autores principales: Wang, Zhe, Yang, Aimin, Yang, Jing, Zhao, Weihong, Wang, Zhilian, Wang, Wei, Wang, Jintao, Song, Jinghui, Li, Li, Lv, Weiguo, Li, Dongyan, Liu, Huiqiang, Wang, Chen, Hao, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708219/
https://www.ncbi.nlm.nih.gov/pubmed/33292305
http://dx.doi.org/10.1186/s12986-020-00521-4
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author Wang, Zhe
Yang, Aimin
Yang, Jing
Zhao, Weihong
Wang, Zhilian
Wang, Wei
Wang, Jintao
Song, Jinghui
Li, Li
Lv, Weiguo
Li, Dongyan
Liu, Huiqiang
Wang, Chen
Hao, Min
author_facet Wang, Zhe
Yang, Aimin
Yang, Jing
Zhao, Weihong
Wang, Zhilian
Wang, Wei
Wang, Jintao
Song, Jinghui
Li, Li
Lv, Weiguo
Li, Dongyan
Liu, Huiqiang
Wang, Chen
Hao, Min
author_sort Wang, Zhe
collection PubMed
description BACKGROUND: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. METHODS: Data on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutrient intake quartile relative to that in the highest quartile. RESULTS: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR = 1.55, 95% CI 1.03–2.33). Similar results were also observed for vitamin B6 (OR = 1.63, 95% CI 1.08–2.46), vitamin C (OR = 1.59, 95% CI 1.05–2.42), niacin (OR = 1.65, 95% CI 1.08–2.51), and vitamin K (second versus fourth quartile: OR = 1.60, 95% CI 1.05–2.44). CONCLUSIONS: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (https://www.chictr.org.cn).
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spelling pubmed-77082192020-12-02 Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study Wang, Zhe Yang, Aimin Yang, Jing Zhao, Weihong Wang, Zhilian Wang, Wei Wang, Jintao Song, Jinghui Li, Li Lv, Weiguo Li, Dongyan Liu, Huiqiang Wang, Chen Hao, Min Nutr Metab (Lond) Research BACKGROUND: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. METHODS: Data on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutrient intake quartile relative to that in the highest quartile. RESULTS: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR = 1.55, 95% CI 1.03–2.33). Similar results were also observed for vitamin B6 (OR = 1.63, 95% CI 1.08–2.46), vitamin C (OR = 1.59, 95% CI 1.05–2.42), niacin (OR = 1.65, 95% CI 1.08–2.51), and vitamin K (second versus fourth quartile: OR = 1.60, 95% CI 1.05–2.44). CONCLUSIONS: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (https://www.chictr.org.cn). BioMed Central 2020-11-30 /pmc/articles/PMC7708219/ /pubmed/33292305 http://dx.doi.org/10.1186/s12986-020-00521-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Zhe
Yang, Aimin
Yang, Jing
Zhao, Weihong
Wang, Zhilian
Wang, Wei
Wang, Jintao
Song, Jinghui
Li, Li
Lv, Weiguo
Li, Dongyan
Liu, Huiqiang
Wang, Chen
Hao, Min
Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
title Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
title_full Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
title_fullStr Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
title_full_unstemmed Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
title_short Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
title_sort dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a chinese population-based study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708219/
https://www.ncbi.nlm.nih.gov/pubmed/33292305
http://dx.doi.org/10.1186/s12986-020-00521-4
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