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Cryptic Plasmodium chronic infections: was Maurizio Ascoli right?
Cryptic Plasmodium niches outside the liver possibly represent a major source of hypnozoite-unrelated recrudescences in malaria. Maurizio Ascoli, an Italian physician and scientist, suggested that infection was maintained as a result of the persistence of endoerythrocytic parasites in the circulator...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708240/ https://www.ncbi.nlm.nih.gov/pubmed/33256745 http://dx.doi.org/10.1186/s12936-020-03516-x |
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author | Monteiro, Wuelton Brito-Sousa, José Diego Elizalde-Torrent, Aleix Bôtto-Menezes, Camila Melo, Gisely Cardoso Fernandez-Becerra, Carmen Lacerda, Marcus del Portillo, Hernando A. |
author_facet | Monteiro, Wuelton Brito-Sousa, José Diego Elizalde-Torrent, Aleix Bôtto-Menezes, Camila Melo, Gisely Cardoso Fernandez-Becerra, Carmen Lacerda, Marcus del Portillo, Hernando A. |
author_sort | Monteiro, Wuelton |
collection | PubMed |
description | Cryptic Plasmodium niches outside the liver possibly represent a major source of hypnozoite-unrelated recrudescences in malaria. Maurizio Ascoli, an Italian physician and scientist, suggested that infection was maintained as a result of the persistence of endoerythrocytic parasites in the circulatory bed of some internal organs, mainly the spleen. This would explain a proportion of the recurrences in patients, regardless of the Plasmodium species. Ascoli proposed a method that included the co-administration of adrenaline, in order to induce splenic contraction, and quinine to clear expelled forms in major vessels. Driven by controversy regarding safety and effectiveness, along with the introduction of new drugs, the Ascoli method was abandoned and mostly forgotten by the malaria research community. To date, however, the existence of cryptic parasites outside the liver is gaining supportive data. This work is a historical retrospective of cryptic malaria infections and the Ascoli method, highlighting key knowledge gaps regarding these possible parasite reservoirs. |
format | Online Article Text |
id | pubmed-7708240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77082402020-12-02 Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? Monteiro, Wuelton Brito-Sousa, José Diego Elizalde-Torrent, Aleix Bôtto-Menezes, Camila Melo, Gisely Cardoso Fernandez-Becerra, Carmen Lacerda, Marcus del Portillo, Hernando A. Malar J Review Cryptic Plasmodium niches outside the liver possibly represent a major source of hypnozoite-unrelated recrudescences in malaria. Maurizio Ascoli, an Italian physician and scientist, suggested that infection was maintained as a result of the persistence of endoerythrocytic parasites in the circulatory bed of some internal organs, mainly the spleen. This would explain a proportion of the recurrences in patients, regardless of the Plasmodium species. Ascoli proposed a method that included the co-administration of adrenaline, in order to induce splenic contraction, and quinine to clear expelled forms in major vessels. Driven by controversy regarding safety and effectiveness, along with the introduction of new drugs, the Ascoli method was abandoned and mostly forgotten by the malaria research community. To date, however, the existence of cryptic parasites outside the liver is gaining supportive data. This work is a historical retrospective of cryptic malaria infections and the Ascoli method, highlighting key knowledge gaps regarding these possible parasite reservoirs. BioMed Central 2020-11-30 /pmc/articles/PMC7708240/ /pubmed/33256745 http://dx.doi.org/10.1186/s12936-020-03516-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Monteiro, Wuelton Brito-Sousa, José Diego Elizalde-Torrent, Aleix Bôtto-Menezes, Camila Melo, Gisely Cardoso Fernandez-Becerra, Carmen Lacerda, Marcus del Portillo, Hernando A. Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? |
title | Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? |
title_full | Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? |
title_fullStr | Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? |
title_full_unstemmed | Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? |
title_short | Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? |
title_sort | cryptic plasmodium chronic infections: was maurizio ascoli right? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708240/ https://www.ncbi.nlm.nih.gov/pubmed/33256745 http://dx.doi.org/10.1186/s12936-020-03516-x |
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