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Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome

Psoriasis is a chronic, refractory, systemic inflammatory skin disease. Traditional Chinese medicine (TCM) shows unique advantage in the treatment of psoriasis based on syndrome differentiation. An untargeted high-throughput metabonomics method based on liquid chromatography coupled to mass spectrom...

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Autores principales: Li, Li, Yao, Dan-ni, Lu, Yue, Deng, Jing-wen, Wei, Jian-an, Yan, Yu-hong, Deng, Hao, Han, Ling, Lu, Chuan-jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708332/
https://www.ncbi.nlm.nih.gov/pubmed/33312124
http://dx.doi.org/10.3389/fphar.2020.558731
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author Li, Li
Yao, Dan-ni
Lu, Yue
Deng, Jing-wen
Wei, Jian-an
Yan, Yu-hong
Deng, Hao
Han, Ling
Lu, Chuan-jian
author_facet Li, Li
Yao, Dan-ni
Lu, Yue
Deng, Jing-wen
Wei, Jian-an
Yan, Yu-hong
Deng, Hao
Han, Ling
Lu, Chuan-jian
author_sort Li, Li
collection PubMed
description Psoriasis is a chronic, refractory, systemic inflammatory skin disease. Traditional Chinese medicine (TCM) shows unique advantage in the treatment of psoriasis based on syndrome differentiation. An untargeted high-throughput metabonomics method based on liquid chromatography coupled to mass spectrometry was applied to study the serum metabolic characteristics in different TCM syndrome types in patients with psoriasis vulgaris (PV), and to discover potential serum biomarkers for its pathogenesis on the endogenous metabolite differentiation basis. The serum metabolic profiles of 45 healthy controls and 124 patients with PV (50 in the blood-stasis group, 30 in the blood-heat group, and 44 in the blood-dryness group) were acquired. The raw spectrometric data were processed using multivariate statistical analysis, and 14 biomarkers related to TCM syndrome differentiation and psoriasis types were screened and identified. The blood-stasis syndrome group showed abnormal lipid metabolism, which was characterized by a low level of phosphatidylcholine (PC) and a high level of lysophosphatidylcholine (LPC). We propose that platelet-activating factor can be applied as a potential biomarker in clinical diagnosis and differentiation of PV with blood-stasis syndrome. The difference in the serum metabolites among PV types with different TCM syndromes and healthy control group illustrated the objective material basis in TCM syndrome differentiation and classification of psoriasis.
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spelling pubmed-77083322020-12-11 Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome Li, Li Yao, Dan-ni Lu, Yue Deng, Jing-wen Wei, Jian-an Yan, Yu-hong Deng, Hao Han, Ling Lu, Chuan-jian Front Pharmacol Pharmacology Psoriasis is a chronic, refractory, systemic inflammatory skin disease. Traditional Chinese medicine (TCM) shows unique advantage in the treatment of psoriasis based on syndrome differentiation. An untargeted high-throughput metabonomics method based on liquid chromatography coupled to mass spectrometry was applied to study the serum metabolic characteristics in different TCM syndrome types in patients with psoriasis vulgaris (PV), and to discover potential serum biomarkers for its pathogenesis on the endogenous metabolite differentiation basis. The serum metabolic profiles of 45 healthy controls and 124 patients with PV (50 in the blood-stasis group, 30 in the blood-heat group, and 44 in the blood-dryness group) were acquired. The raw spectrometric data were processed using multivariate statistical analysis, and 14 biomarkers related to TCM syndrome differentiation and psoriasis types were screened and identified. The blood-stasis syndrome group showed abnormal lipid metabolism, which was characterized by a low level of phosphatidylcholine (PC) and a high level of lysophosphatidylcholine (LPC). We propose that platelet-activating factor can be applied as a potential biomarker in clinical diagnosis and differentiation of PV with blood-stasis syndrome. The difference in the serum metabolites among PV types with different TCM syndromes and healthy control group illustrated the objective material basis in TCM syndrome differentiation and classification of psoriasis. Frontiers Media S.A. 2020-11-18 /pmc/articles/PMC7708332/ /pubmed/33312124 http://dx.doi.org/10.3389/fphar.2020.558731 Text en Copyright © 2020 Li, Yao, Lu, Deng, Wei, Yan, Deng, Han and Lu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Li
Yao, Dan-ni
Lu, Yue
Deng, Jing-wen
Wei, Jian-an
Yan, Yu-hong
Deng, Hao
Han, Ling
Lu, Chuan-jian
Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome
title Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome
title_full Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome
title_fullStr Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome
title_full_unstemmed Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome
title_short Metabonomics Study on Serum Characteristic Metabolites of Psoriasis Vulgaris Patients With Blood-Stasis Syndrome
title_sort metabonomics study on serum characteristic metabolites of psoriasis vulgaris patients with blood-stasis syndrome
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708332/
https://www.ncbi.nlm.nih.gov/pubmed/33312124
http://dx.doi.org/10.3389/fphar.2020.558731
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