Cargando…

Flavonoids: nutraceutical potential for counteracting muscle atrophy

Skeletal muscle plays a vital role in the conversion of chemical energy into physical force. Muscle atrophy, characterized by a reduction in muscle mass, is a symptom of chronic disease (cachexia), aging (sarcopenia), and muscle disuse (inactivity). To date, several trials have been conducted to pre...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Changhee, Hwang, Jae-Kwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708614/
https://www.ncbi.nlm.nih.gov/pubmed/33282430
http://dx.doi.org/10.1007/s10068-020-00816-5
_version_ 1783617574846595072
author Kim, Changhee
Hwang, Jae-Kwan
author_facet Kim, Changhee
Hwang, Jae-Kwan
author_sort Kim, Changhee
collection PubMed
description Skeletal muscle plays a vital role in the conversion of chemical energy into physical force. Muscle atrophy, characterized by a reduction in muscle mass, is a symptom of chronic disease (cachexia), aging (sarcopenia), and muscle disuse (inactivity). To date, several trials have been conducted to prevent and inhibit muscle atrophy development; however, few interventions are currently available for muscle atrophy. Recently, food ingredients, plant extracts, and phytochemicals have received attention as treatment sources to prevent muscle wasting. Flavonoids are bioactive polyphenol compounds found in foods and plants. They possess diverse biological activities, including anti-obesity, anti-diabetes, anti-cancer, anti-oxidation, and anti-inflammation. The effects of flavonoids on muscle atrophy have been investigated by monitoring molecular mechanisms involved in protein turnover, mitochondrial activity, and myogenesis. This review summarizes the reported effects of flavonoids on sarcopenia, cachexia, and disuse muscle atrophy, thus, providing an insight into the understanding of the associated molecular mechanisms.
format Online
Article
Text
id pubmed-7708614
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Singapore
record_format MEDLINE/PubMed
spelling pubmed-77086142020-12-04 Flavonoids: nutraceutical potential for counteracting muscle atrophy Kim, Changhee Hwang, Jae-Kwan Food Sci Biotechnol Article Skeletal muscle plays a vital role in the conversion of chemical energy into physical force. Muscle atrophy, characterized by a reduction in muscle mass, is a symptom of chronic disease (cachexia), aging (sarcopenia), and muscle disuse (inactivity). To date, several trials have been conducted to prevent and inhibit muscle atrophy development; however, few interventions are currently available for muscle atrophy. Recently, food ingredients, plant extracts, and phytochemicals have received attention as treatment sources to prevent muscle wasting. Flavonoids are bioactive polyphenol compounds found in foods and plants. They possess diverse biological activities, including anti-obesity, anti-diabetes, anti-cancer, anti-oxidation, and anti-inflammation. The effects of flavonoids on muscle atrophy have been investigated by monitoring molecular mechanisms involved in protein turnover, mitochondrial activity, and myogenesis. This review summarizes the reported effects of flavonoids on sarcopenia, cachexia, and disuse muscle atrophy, thus, providing an insight into the understanding of the associated molecular mechanisms. Springer Singapore 2020-09-16 /pmc/articles/PMC7708614/ /pubmed/33282430 http://dx.doi.org/10.1007/s10068-020-00816-5 Text en © The Author(s) 2020, corrected publication 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Changhee
Hwang, Jae-Kwan
Flavonoids: nutraceutical potential for counteracting muscle atrophy
title Flavonoids: nutraceutical potential for counteracting muscle atrophy
title_full Flavonoids: nutraceutical potential for counteracting muscle atrophy
title_fullStr Flavonoids: nutraceutical potential for counteracting muscle atrophy
title_full_unstemmed Flavonoids: nutraceutical potential for counteracting muscle atrophy
title_short Flavonoids: nutraceutical potential for counteracting muscle atrophy
title_sort flavonoids: nutraceutical potential for counteracting muscle atrophy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708614/
https://www.ncbi.nlm.nih.gov/pubmed/33282430
http://dx.doi.org/10.1007/s10068-020-00816-5
work_keys_str_mv AT kimchanghee flavonoidsnutraceuticalpotentialforcounteractingmuscleatrophy
AT hwangjaekwan flavonoidsnutraceuticalpotentialforcounteractingmuscleatrophy