Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

Cohesin plays an essential role in chromatin loop extrusion, but its impact on a compartmentalized nuclear architecture, linked to nuclear functions, is less well understood. Using live-cell and super-resolved 3D microscopy, here we find that cohesin depletion in a human colon cancer derived cell li...

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Detalles Bibliográficos
Autores principales: Cremer, Marion, Brandstetter, Katharina, Maiser, Andreas, Rao, Suhas S. P., Schmid, Volker J., Guirao-Ortiz, Miguel, Mitra, Namita, Mamberti, Stefania, Klein, Kyle N., Gilbert, David M., Leonhardt, Heinrich, Cardoso, M. Cristina, Aiden, Erez Lieberman, Harz, Hartmann, Cremer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708632/
https://www.ncbi.nlm.nih.gov/pubmed/33262376
http://dx.doi.org/10.1038/s41467-020-19876-6

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