Cargando…

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Hydrogen-Deuterium eXchange coupled to Mass Spectrometry (HDX-MS) is now common practice in structural biology. However, it is most of the time applied to rather small oligomeric complexes. Here, we report on the use of HDX-MS to investigate conformational differences between the human standard 20S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lesne, Jean, Locard-Paulet, Marie, Parra, Julien, Zivković, Dušan, Menneteau, Thomas, Bousquet, Marie-Pierre, Burlet-Schiltz, Odile, Marcoux, Julien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708635/ https://www.ncbi.nlm.nih.gov/pubmed/33262340 http://dx.doi.org/10.1038/s41467-020-19934-z

Ejemplares similares

HDX-Viewer: interactive 3D visualization of hydrogen–deuterium exchange data
por: Bouyssié, David, et al.
Publicado: (2019)

Top-Down and Intact Protein Mass Spectrometry Data Visualization for Proteoform Analysis Using VisioProt-MS
por: Lesne, Jean, et al.
Publicado: (2019)

VisioProt-MS: interactive 2D maps from intact protein mass spectrometry
por: Locard-Paulet, Marie, et al.
Publicado: (2019)

Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis
por: Živković, Dušan, et al.
Publicado: (2022)

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ
por: Jonik-Nowak, Beata, et al.
Publicado: (2018)

Deciphering preferential interactions within supramolecular protein complexes: the proteasome case
por: Fabre, Bertrand, et al.
Publicado: (2015)

Mass Spectrometry-based Absolute Quantification of 20S Proteasome Status for Controlled Ex-vivo Expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells
por: Menneteau, Thomas, et al.
Publicado: (2019)

Establishing 20S Proteasome Genetic, Translational and Post-Translational Status from Precious Biological and Patient Samples with Top-Down MS
por: Dafun, Angelique Sanchez, et al.
Publicado: (2023)

Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane
por: Chiaradia, Laura, et al.
Publicado: (2017)

Scrutiny of Mycobacterium tuberculosis 19 kDa antigen proteoforms provides new insights in the lipoglycoprotein biogenesis paradigm
por: Parra, Julien, et al.
Publicado: (2017)

Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large‐scale and targeted quantitative proteomics
por: Matondo, Mariette, et al.
Publicado: (2016)

Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination
por: Voisinne, Guillaume, et al.
Publicado: (2022)

PA28αβ: The Enigmatic Magic Ring of the Proteasome?
por: Cascio, Paolo
Publicado: (2014)

A Sentinel in the Crosstalk Between the Nervous and Immune System: The (Immuno)-Proteasome
por: Limanaqi, Fiona, et al.
Publicado: (2019)

PA28γ: New Insights on an Ancient Proteasome Activator
por: Cascio, Paolo
Publicado: (2021)

Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy
por: Yadranji Aghdam, Saeed, et al.
Publicado: (2016)

Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility
por: Huang, Lin, et al.
Publicado: (2016)

The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function
por: Koçberber, Zeynep, et al.
Publicado: (2023)

Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators
por: Thomas, Taylor, et al.
Publicado: (2023)

Downregulation of PA28α induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma
por: Gu, Yanyan, et al.
Publicado: (2020)

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions
por: Locard‐Paulet, Marie, et al.
Publicado: (2020)

Proteasome activator 28γ (PA28γ) allosterically activates trypsin-like proteolysis by binding to the α-ring of the 20S proteasome
por: Thomas, Taylor A., et al.
Publicado: (2022)

Identifying the genes impacted by cell proliferation in proteomics and transcriptomics studies
por: Locard-Paulet, Marie, et al.
Publicado: (2022)

Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
por: Chen, Jinhuan, et al.
Publicado: (2021)

Proteo3Dnet: a web server for the integration of structural information with interactomics data
por: Postic, Guillaume, et al.
Publicado: (2021)

Increased proteasome activator 28 gamma (PA28γ) levels are unspecific but correlate with disease activity in rheumatoid arthritis
por: Gruner, Melanie, et al.
Publicado: (2014)

Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or Pa28
por: van Hall, Thorbald, et al.
Publicado: (2000)

Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28
por: Hernebring, Malin, et al.
Publicado: (2013)

Proteasome activator PA28γ-dependent degradation of coronavirus disease (COVID-19) nucleocapsid protein
por: Zhang, Haiyang, et al.
Publicado: (2020)

Structural insights into the human PA28–20S proteasome enabled by efficient tagging and purification of endogenous proteins
por: Zhao, Jianhua, et al.
Publicado: (2022)

(Immuno)proteasomes as therapeutic target in acute leukemia
por: Cloos, Jacqueline, et al.
Publicado: (2017)

Proteasome activator PA28γ regulates p53 by enhancing its MDM2-mediated degradation
por: Zhang, Zhuo, et al.
Publicado: (2008)

Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma
por: Feng, Xiaodong, et al.
Publicado: (2016)

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity
por: Adelöf, Julia, et al.
Publicado: (2018)

Brain-Derived 11S Regulator (PA28αβ) Promotes Proteasomal Hydrolysis of Elongated Oligoglutamine-Containing Peptides
por: Kriachkov, Viacheslav A., et al.
Publicado: (2023)

Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins
por: Abi Habib, Joanna, et al.
Publicado: (2020)

The Proteasome Activator PA28γ, a Negative Regulator of p53, Is Transcriptionally Up-Regulated by p53
por: Wan, Zhen-Xing, et al.
Publicado: (2014)

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes
por: Lee, Hyun Ju, et al.
Publicado: (2023)

Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
por: van Scheppingen, J., et al.
Publicado: (2016)

LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry
por: Yang, Yiying, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6u0scfkkcbpr9u9mtm83slbtf7