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Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat

Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning...

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Autores principales: Pezze, Marie A, Marshall, Hayley J, Cassaday, Helen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708664/
https://www.ncbi.nlm.nih.gov/pubmed/33161817
http://dx.doi.org/10.1177/0269881120965914
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author Pezze, Marie A
Marshall, Hayley J
Cassaday, Helen J
author_facet Pezze, Marie A
Marshall, Hayley J
Cassaday, Helen J
author_sort Pezze, Marie A
collection PubMed
description Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning. A noise stimulus was followed by a 1 mA footshock, with or without a 10-second trace interval between these events in a conditioned suppression procedure. The trace-conditioned groups (10 seconds) showed less test suppression than the control-conditioned groups (0 seconds). Counter to prediction, there was no effect of muscimol infusion on suppression to the noise stimulus in the 10-second trace groups.
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spelling pubmed-77086642020-12-08 Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat Pezze, Marie A Marshall, Hayley J Cassaday, Helen J J Psychopharmacol Null Results in Brief Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning. A noise stimulus was followed by a 1 mA footshock, with or without a 10-second trace interval between these events in a conditioned suppression procedure. The trace-conditioned groups (10 seconds) showed less test suppression than the control-conditioned groups (0 seconds). Counter to prediction, there was no effect of muscimol infusion on suppression to the noise stimulus in the 10-second trace groups. SAGE Publications 2020-11-08 2020-12 /pmc/articles/PMC7708664/ /pubmed/33161817 http://dx.doi.org/10.1177/0269881120965914 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Null Results in Brief
Pezze, Marie A
Marshall, Hayley J
Cassaday, Helen J
Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
title Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
title_full Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
title_fullStr Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
title_full_unstemmed Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
title_short Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
title_sort muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
topic Null Results in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708664/
https://www.ncbi.nlm.nih.gov/pubmed/33161817
http://dx.doi.org/10.1177/0269881120965914
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