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Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat
Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708664/ https://www.ncbi.nlm.nih.gov/pubmed/33161817 http://dx.doi.org/10.1177/0269881120965914 |
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author | Pezze, Marie A Marshall, Hayley J Cassaday, Helen J |
author_facet | Pezze, Marie A Marshall, Hayley J Cassaday, Helen J |
author_sort | Pezze, Marie A |
collection | PubMed |
description | Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning. A noise stimulus was followed by a 1 mA footshock, with or without a 10-second trace interval between these events in a conditioned suppression procedure. The trace-conditioned groups (10 seconds) showed less test suppression than the control-conditioned groups (0 seconds). Counter to prediction, there was no effect of muscimol infusion on suppression to the noise stimulus in the 10-second trace groups. |
format | Online Article Text |
id | pubmed-7708664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77086642020-12-08 Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat Pezze, Marie A Marshall, Hayley J Cassaday, Helen J J Psychopharmacol Null Results in Brief Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning. A noise stimulus was followed by a 1 mA footshock, with or without a 10-second trace interval between these events in a conditioned suppression procedure. The trace-conditioned groups (10 seconds) showed less test suppression than the control-conditioned groups (0 seconds). Counter to prediction, there was no effect of muscimol infusion on suppression to the noise stimulus in the 10-second trace groups. SAGE Publications 2020-11-08 2020-12 /pmc/articles/PMC7708664/ /pubmed/33161817 http://dx.doi.org/10.1177/0269881120965914 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Null Results in Brief Pezze, Marie A Marshall, Hayley J Cassaday, Helen J Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat |
title | Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat |
title_full | Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat |
title_fullStr | Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat |
title_full_unstemmed | Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat |
title_short | Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat |
title_sort | muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat |
topic | Null Results in Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708664/ https://www.ncbi.nlm.nih.gov/pubmed/33161817 http://dx.doi.org/10.1177/0269881120965914 |
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