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Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression

Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depr...

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Autores principales: Capitão, Liliana P, Chapman, Robert, Filippini, Nicola, Wright, Lucy, Murphy, Susannah E, James, Anthony, Cowen, Phil J, Harmer, Catherine J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708665/
https://www.ncbi.nlm.nih.gov/pubmed/33143532
http://dx.doi.org/10.1177/0269881120959608
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author Capitão, Liliana P
Chapman, Robert
Filippini, Nicola
Wright, Lucy
Murphy, Susannah E
James, Anthony
Cowen, Phil J
Harmer, Catherine J
author_facet Capitão, Liliana P
Chapman, Robert
Filippini, Nicola
Wright, Lucy
Murphy, Susannah E
James, Anthony
Cowen, Phil J
Harmer, Catherine J
author_sort Capitão, Liliana P
collection PubMed
description Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults that have demonstrated an acute effect of antidepressants on activity within the default mode network, a single dose of fluoxetine did not alter activity in this network in adolescent depression. There were unexpected group activity differences in the motor network, which should be clarified in future research.
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spelling pubmed-77086652020-12-08 Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression Capitão, Liliana P Chapman, Robert Filippini, Nicola Wright, Lucy Murphy, Susannah E James, Anthony Cowen, Phil J Harmer, Catherine J J Psychopharmacol Null Results in Brief Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults that have demonstrated an acute effect of antidepressants on activity within the default mode network, a single dose of fluoxetine did not alter activity in this network in adolescent depression. There were unexpected group activity differences in the motor network, which should be clarified in future research. SAGE Publications 2020-11-04 2020-12 /pmc/articles/PMC7708665/ /pubmed/33143532 http://dx.doi.org/10.1177/0269881120959608 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Null Results in Brief
Capitão, Liliana P
Chapman, Robert
Filippini, Nicola
Wright, Lucy
Murphy, Susannah E
James, Anthony
Cowen, Phil J
Harmer, Catherine J
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
title Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
title_full Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
title_fullStr Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
title_full_unstemmed Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
title_short Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
title_sort neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
topic Null Results in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708665/
https://www.ncbi.nlm.nih.gov/pubmed/33143532
http://dx.doi.org/10.1177/0269881120959608
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