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Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression

OBJECTIVE: Regulator of calcineurin 1 (RCAN1) controls plasticity of the nervous system and depressive conditions by regulating brain-derived neurotropic factor (BDNF) and plays a crucial role in neural and cardiac pathways. The apolipoprotein E gene (ApoE) is a robust risk factor for progression of...

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Autores principales: Shuo, Wang, Li, Haicong, Muneko, Nishijo, Yoshikazu, Nishino, Kato, Nobuo, Kasamaki, Yuji, Ueda, Tadashi, Kanda, Tsugiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708711/
https://www.ncbi.nlm.nih.gov/pubmed/33251902
http://dx.doi.org/10.1177/0300060520964016
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author Shuo, Wang
Li, Haicong
Muneko, Nishijo
Yoshikazu, Nishino
Kato, Nobuo
Kasamaki, Yuji
Ueda, Tadashi
Kanda, Tsugiyasu
author_facet Shuo, Wang
Li, Haicong
Muneko, Nishijo
Yoshikazu, Nishino
Kato, Nobuo
Kasamaki, Yuji
Ueda, Tadashi
Kanda, Tsugiyasu
author_sort Shuo, Wang
collection PubMed
description OBJECTIVE: Regulator of calcineurin 1 (RCAN1) controls plasticity of the nervous system and depressive conditions by regulating brain-derived neurotropic factor (BDNF) and plays a crucial role in neural and cardiac pathways. The apolipoprotein E gene (ApoE) is a robust risk factor for progression of Alzheimer’s disease. A fatty diet is considered detrimental for metabolic disorders, such as obesity and cardiovascular diseases. METHODS: We examined the neuronal and cardiac protective roles of RCAN1 in ApoE−/− mice that were fed a high- or low-fat diet with and without voluntary movement for 3 months. Organ weights, laboratory data, histology, RNA expression, and behavior were examined. RESULTS: A high-fat diet with exercise improved depressive function, as examined by the forced swimming test, and RCAN1 mRNA expression was induced in the hippocampus. A low-fat diet with exercise resulted in a reduced body weight, higher heart weight/body weight ratio, and lower circulating triglyceride levels compared with a low-fat diet without exercise. RCAN1 mRNA expression was increased in cardiomyocytes in ApoE−/− mice. CONCLUSIONS: The combination of a high-fat diet and exercise might reduce depressive function, whereas a low-fat diet with exercise leads to cardioprotection. Induction of RCAN1 expression might affect neuroplasticity and cardiac function.
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spelling pubmed-77087112020-12-07 Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression Shuo, Wang Li, Haicong Muneko, Nishijo Yoshikazu, Nishino Kato, Nobuo Kasamaki, Yuji Ueda, Tadashi Kanda, Tsugiyasu J Int Med Res Pre-Clinical Research Report OBJECTIVE: Regulator of calcineurin 1 (RCAN1) controls plasticity of the nervous system and depressive conditions by regulating brain-derived neurotropic factor (BDNF) and plays a crucial role in neural and cardiac pathways. The apolipoprotein E gene (ApoE) is a robust risk factor for progression of Alzheimer’s disease. A fatty diet is considered detrimental for metabolic disorders, such as obesity and cardiovascular diseases. METHODS: We examined the neuronal and cardiac protective roles of RCAN1 in ApoE−/− mice that were fed a high- or low-fat diet with and without voluntary movement for 3 months. Organ weights, laboratory data, histology, RNA expression, and behavior were examined. RESULTS: A high-fat diet with exercise improved depressive function, as examined by the forced swimming test, and RCAN1 mRNA expression was induced in the hippocampus. A low-fat diet with exercise resulted in a reduced body weight, higher heart weight/body weight ratio, and lower circulating triglyceride levels compared with a low-fat diet without exercise. RCAN1 mRNA expression was increased in cardiomyocytes in ApoE−/− mice. CONCLUSIONS: The combination of a high-fat diet and exercise might reduce depressive function, whereas a low-fat diet with exercise leads to cardioprotection. Induction of RCAN1 expression might affect neuroplasticity and cardiac function. SAGE Publications 2020-11-29 /pmc/articles/PMC7708711/ /pubmed/33251902 http://dx.doi.org/10.1177/0300060520964016 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Pre-Clinical Research Report
Shuo, Wang
Li, Haicong
Muneko, Nishijo
Yoshikazu, Nishino
Kato, Nobuo
Kasamaki, Yuji
Ueda, Tadashi
Kanda, Tsugiyasu
Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
title Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
title_full Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
title_fullStr Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
title_full_unstemmed Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
title_short Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
title_sort combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein e knockout mice with a change in rcan1 expression
topic Pre-Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708711/
https://www.ncbi.nlm.nih.gov/pubmed/33251902
http://dx.doi.org/10.1177/0300060520964016
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