Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection

We analyzed the expression of ACE2 in the pharyngeal epithelium and examined its relationship with clinical features and serological parameters in patients with upper respiratory infection (URI). The expression level of the ACE2 gene was significantly higher in patients with URI (n = 125) than in he...

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Autores principales: Zhang, Mingjiao, Du, Lingyan, Faleti, Oluwasijibomi Damola, Huang, Jing, Xiao, Gang, Lyu, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708802/
https://www.ncbi.nlm.nih.gov/pubmed/33278618
http://dx.doi.org/10.1016/j.ijid.2020.11.197
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author Zhang, Mingjiao
Du, Lingyan
Faleti, Oluwasijibomi Damola
Huang, Jing
Xiao, Gang
Lyu, Xiaoming
author_facet Zhang, Mingjiao
Du, Lingyan
Faleti, Oluwasijibomi Damola
Huang, Jing
Xiao, Gang
Lyu, Xiaoming
author_sort Zhang, Mingjiao
collection PubMed
description We analyzed the expression of ACE2 in the pharyngeal epithelium and examined its relationship with clinical features and serological parameters in patients with upper respiratory infection (URI). The expression level of the ACE2 gene was significantly higher in patients with URI (n = 125) than in healthy control (HC) individuals (n = 52) (p < 0.0001). The ACE2 gene expression level was significantly and positively correlated with age (r=0.1799, p = 0.0447) and body temperature (r=0.1927, p = 0.0427), which may help explain increasing coinfections with SARS-CoV-2 and other respiratory pathogens.
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spelling pubmed-77088022020-12-02 Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection Zhang, Mingjiao Du, Lingyan Faleti, Oluwasijibomi Damola Huang, Jing Xiao, Gang Lyu, Xiaoming Int J Infect Dis Article We analyzed the expression of ACE2 in the pharyngeal epithelium and examined its relationship with clinical features and serological parameters in patients with upper respiratory infection (URI). The expression level of the ACE2 gene was significantly higher in patients with URI (n = 125) than in healthy control (HC) individuals (n = 52) (p < 0.0001). The ACE2 gene expression level was significantly and positively correlated with age (r=0.1799, p = 0.0447) and body temperature (r=0.1927, p = 0.0427), which may help explain increasing coinfections with SARS-CoV-2 and other respiratory pathogens. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-02 2020-12-02 /pmc/articles/PMC7708802/ /pubmed/33278618 http://dx.doi.org/10.1016/j.ijid.2020.11.197 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Mingjiao
Du, Lingyan
Faleti, Oluwasijibomi Damola
Huang, Jing
Xiao, Gang
Lyu, Xiaoming
Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection
title Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection
title_full Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection
title_fullStr Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection
title_full_unstemmed Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection
title_short Higher pharyngeal epithelial gene expression of angiotensin-converting Enzyme-2 in patients with upper respiratory infection
title_sort higher pharyngeal epithelial gene expression of angiotensin-converting enzyme-2 in patients with upper respiratory infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708802/
https://www.ncbi.nlm.nih.gov/pubmed/33278618
http://dx.doi.org/10.1016/j.ijid.2020.11.197
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