Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43(266-283)

BACKGROUND: Glioblastoma is the most aggressive primary brain tumour and has a very poor prognosis. Inhibition of c-Src activity in glioblastoma stem cells (GSCs, responsible for glioblastoma lethality) and primary glioblastoma cells by the peptide TAT-Cx43(266–283) reduces tumorigenicity, and boost...

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Detalles Bibliográficos
Autores principales: Pelaz, Sara G., Jaraíz-Rodríguez, Myriam, Álvarez-Vázquez, Andrea, Talaverón, Rocío, García-Vicente, Laura, Flores-Hernández, Raquel, Gómez de Cedrón, Marta, Tabernero, María, Ramírez de Molina, Ana, Lillo, Concepción, Medina, José M., Tabernero, Arantxa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708820/
https://www.ncbi.nlm.nih.gov/pubmed/33254027
http://dx.doi.org/10.1016/j.ebiom.2020.103134

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