Towards a unified open access dataset of molecular interactions

The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has...

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Autores principales: Porras, Pablo, Barrera, Elisabet, Bridge, Alan, del-Toro, Noemi, Cesareni, Gianni, Duesbury, Margaret, Hermjakob, Henning, Iannuccelli, Marta, Jurisica, Igor, Kotlyar, Max, Licata, Luana, Lovering, Ruth C., Lynn, David J., Meldal, Birgit, Nanduri, Bindu, Paneerselvam, Kalpana, Panni, Simona, Pastrello, Chiara, Pellegrini, Matteo, Perfetto, Livia, Rahimzadeh, Negin, Ratan, Prashansa, Ricard-Blum, Sylvie, Salwinski, Lukasz, Shirodkar, Gautam, Shrivastava, Anjalia, Orchard, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708836/
https://www.ncbi.nlm.nih.gov/pubmed/33262342
http://dx.doi.org/10.1038/s41467-020-19942-z
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author Porras, Pablo
Barrera, Elisabet
Bridge, Alan
del-Toro, Noemi
Cesareni, Gianni
Duesbury, Margaret
Hermjakob, Henning
Iannuccelli, Marta
Jurisica, Igor
Kotlyar, Max
Licata, Luana
Lovering, Ruth C.
Lynn, David J.
Meldal, Birgit
Nanduri, Bindu
Paneerselvam, Kalpana
Panni, Simona
Pastrello, Chiara
Pellegrini, Matteo
Perfetto, Livia
Rahimzadeh, Negin
Ratan, Prashansa
Ricard-Blum, Sylvie
Salwinski, Lukasz
Shirodkar, Gautam
Shrivastava, Anjalia
Orchard, Sandra
author_facet Porras, Pablo
Barrera, Elisabet
Bridge, Alan
del-Toro, Noemi
Cesareni, Gianni
Duesbury, Margaret
Hermjakob, Henning
Iannuccelli, Marta
Jurisica, Igor
Kotlyar, Max
Licata, Luana
Lovering, Ruth C.
Lynn, David J.
Meldal, Birgit
Nanduri, Bindu
Paneerselvam, Kalpana
Panni, Simona
Pastrello, Chiara
Pellegrini, Matteo
Perfetto, Livia
Rahimzadeh, Negin
Ratan, Prashansa
Ricard-Blum, Sylvie
Salwinski, Lukasz
Shirodkar, Gautam
Shrivastava, Anjalia
Orchard, Sandra
author_sort Porras, Pablo
collection PubMed
description The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.
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spelling pubmed-77088362020-12-03 Towards a unified open access dataset of molecular interactions Porras, Pablo Barrera, Elisabet Bridge, Alan del-Toro, Noemi Cesareni, Gianni Duesbury, Margaret Hermjakob, Henning Iannuccelli, Marta Jurisica, Igor Kotlyar, Max Licata, Luana Lovering, Ruth C. Lynn, David J. Meldal, Birgit Nanduri, Bindu Paneerselvam, Kalpana Panni, Simona Pastrello, Chiara Pellegrini, Matteo Perfetto, Livia Rahimzadeh, Negin Ratan, Prashansa Ricard-Blum, Sylvie Salwinski, Lukasz Shirodkar, Gautam Shrivastava, Anjalia Orchard, Sandra Nat Commun Perspective The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources. Nature Publishing Group UK 2020-12-01 /pmc/articles/PMC7708836/ /pubmed/33262342 http://dx.doi.org/10.1038/s41467-020-19942-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Porras, Pablo
Barrera, Elisabet
Bridge, Alan
del-Toro, Noemi
Cesareni, Gianni
Duesbury, Margaret
Hermjakob, Henning
Iannuccelli, Marta
Jurisica, Igor
Kotlyar, Max
Licata, Luana
Lovering, Ruth C.
Lynn, David J.
Meldal, Birgit
Nanduri, Bindu
Paneerselvam, Kalpana
Panni, Simona
Pastrello, Chiara
Pellegrini, Matteo
Perfetto, Livia
Rahimzadeh, Negin
Ratan, Prashansa
Ricard-Blum, Sylvie
Salwinski, Lukasz
Shirodkar, Gautam
Shrivastava, Anjalia
Orchard, Sandra
Towards a unified open access dataset of molecular interactions
title Towards a unified open access dataset of molecular interactions
title_full Towards a unified open access dataset of molecular interactions
title_fullStr Towards a unified open access dataset of molecular interactions
title_full_unstemmed Towards a unified open access dataset of molecular interactions
title_short Towards a unified open access dataset of molecular interactions
title_sort towards a unified open access dataset of molecular interactions
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708836/
https://www.ncbi.nlm.nih.gov/pubmed/33262342
http://dx.doi.org/10.1038/s41467-020-19942-z
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