STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction

STAT3 is a transcription factor involved in several cellular activities including inflammation, proliferation, and survival, but it also plays a non-transcriptional role in modulating mitochondrial metabolism. Given its diverse functions in human cancers, it is an emerging therapeutic target. Here w...

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Detalles Bibliográficos
Autores principales: Brambilla, Lara, Lahiri, Tanaya, Cammer, Michael, Levy, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708861/
https://www.ncbi.nlm.nih.gov/pubmed/33305182
http://dx.doi.org/10.1016/j.isci.2020.101822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708861/
https://www.ncbi.nlm.nih.gov/pubmed/33305182
http://dx.doi.org/10.1016/j.isci.2020.101822

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