Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy

Pharmacological ascorbate (P-AscH(-)) combined with standard of care (SOC) radiation and temozolomide is being evaluated in a phase 2 clinical trial (NCT02344355) in the treatment of glioblastoma (GBM). Previously published data demonstrated that paramagnetic iron (Fe(3+)) catalyzes ascorbate's...

Descripción completa

Detalles Bibliográficos
Autores principales: Cushing, Cameron M., Petronek, Michael S., Bodeker, Kellie L., Vollstedt, Sandy, Brown, Heather A., Opat, Emyleigh, Hollenbeck, Nancy J., Shanks, Thomas, Berg, Daniel J., Smith, Brian J., Smith, Mark C., Monga, Varun, Furqan, Muhammad, Howard, Matthew A., Greenlee, Jeremy D., Mapuskar, Kranti A., St-Aubin, Joel, Flynn, Ryan T., Cullen, Joseph J., Buettner, Garry R., Spitz, Douglas R., Buatti, John M., Allen, Bryan G., Magnotta, Vincent A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708874/
https://www.ncbi.nlm.nih.gov/pubmed/33260088
http://dx.doi.org/10.1016/j.redox.2020.101804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708874/
https://www.ncbi.nlm.nih.gov/pubmed/33260088
http://dx.doi.org/10.1016/j.redox.2020.101804

Ejemplares similares