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A combined NMR and EPR investigation on the effect of the disordered RGG regions in the structure and the activity of the RRM domain of FUS

Structural disorder represents a key feature in the mechanism of action of RNA-binding proteins (RBPs). Recent insights revealed that intrinsically disordered regions (IDRs) linking globular domains modulate their capability to interact with various sequences of RNA, but also regulate aggregation pr...

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Detalles Bibliográficos
Autores principales:	Bonucci, A., Murrali, M. G., Banci, L., Pierattelli, R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708983/ https://www.ncbi.nlm.nih.gov/pubmed/33262375 http://dx.doi.org/10.1038/s41598-020-77899-x

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