IL3RA-Targeting Antibody–Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies

SIMPLE SUMMARY: IL3RA (alpha subunit of the interleukin 3 receptor) is a cell membrane protein frequently expressed in acute myeloid leukemia (AML) and Hodgkin lymphoma; therefore, it is a promising therapeutic target for cancer treatment. Here, we introduce BAY-943, a novel IL3RA-targeting antibody...

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Detalles Bibliográficos
Autores principales: Kirchhoff, Dennis, Stelte-Ludwig, Beatrix, Lerchen, Hans-Georg, Wengner, Antje Margret, von Ahsen, Oliver, Buchmann, Pascale, Märsch, Stephan, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Erkelenz, Michael, Zierz, Ruprecht, Johanssen, Sandra, Mumberg, Dominik, Sommer, Anette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709048/
https://www.ncbi.nlm.nih.gov/pubmed/33233768
http://dx.doi.org/10.3390/cancers12113464

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