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Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx

High-dose-rate interstitial brachytherapy (HDR-ISBT) is relatively rarely applied for the head and neck cancer because of its anatomical complexity and difficulty of applicator placement. However, its dose distribution is more confined even better than intensity-modulated radiation therapy (IMRT) an...

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Autores principales: Murakami, Naoya, Yoshimoto, Seiichi, Uematsu, Masakazu, Kashihara, Tairo, Takahashi, Kana, Inaba, Koji, Okuma, Kae, Igaki, Hiroshi, Nakayama, Yuko, Masui, Koji, Yoshida, Ken, Itami, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709071/
https://www.ncbi.nlm.nih.gov/pubmed/33299579
http://dx.doi.org/10.1259/bjrcr.20200005
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author Murakami, Naoya
Yoshimoto, Seiichi
Uematsu, Masakazu
Kashihara, Tairo
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Igaki, Hiroshi
Nakayama, Yuko
Masui, Koji
Yoshida, Ken
Itami, Jun
author_facet Murakami, Naoya
Yoshimoto, Seiichi
Uematsu, Masakazu
Kashihara, Tairo
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Igaki, Hiroshi
Nakayama, Yuko
Masui, Koji
Yoshida, Ken
Itami, Jun
author_sort Murakami, Naoya
collection PubMed
description High-dose-rate interstitial brachytherapy (HDR-ISBT) is relatively rarely applied for the head and neck cancer because of its anatomical complexity and difficulty of applicator placement. However, its dose distribution is more confined even better than intensity-modulated radiation therapy (IMRT) and can deliver a higher dose while sparing surrounding normal tissues. In this case report, the effectiveness of HDR-ISBT as a boost following IMRT for keratinizing squamous cell carcinoma of nasopharynx was presented. A 76-year-old female who suffered from cT3N0M0 keratinizing squamous cell carcinoma of the nasopharynx was treated with definitive concurrent chemoradiation therapy involving IMRT. However, physical examination and laryngoscope fibre finding showed evident residual tumour at 60 Gy of IMRT, then, boost HDR-ISBT was proposed. After delivering 66 Gy of IMRT, CT image-guided HDR-ISBT 4 Gy in a single fraction was performed under local anaesthesia and sedation. MRI taken 5 months after HDR-ISBT showed remarkable shrinkage of the primary tumour. After HDR-ISBT, the remaining session of IMRT was delivered from the next day until 70 Gy in 35 fractions. It was demonstrated that boost HDR-ISBT combined with IMRT for keratinizing squamous cell carcinoma of the nasopharynx was performed safely and showed favourable efficacy.
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spelling pubmed-77090712020-12-08 Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx Murakami, Naoya Yoshimoto, Seiichi Uematsu, Masakazu Kashihara, Tairo Takahashi, Kana Inaba, Koji Okuma, Kae Igaki, Hiroshi Nakayama, Yuko Masui, Koji Yoshida, Ken Itami, Jun BJR Case Rep Case Report High-dose-rate interstitial brachytherapy (HDR-ISBT) is relatively rarely applied for the head and neck cancer because of its anatomical complexity and difficulty of applicator placement. However, its dose distribution is more confined even better than intensity-modulated radiation therapy (IMRT) and can deliver a higher dose while sparing surrounding normal tissues. In this case report, the effectiveness of HDR-ISBT as a boost following IMRT for keratinizing squamous cell carcinoma of nasopharynx was presented. A 76-year-old female who suffered from cT3N0M0 keratinizing squamous cell carcinoma of the nasopharynx was treated with definitive concurrent chemoradiation therapy involving IMRT. However, physical examination and laryngoscope fibre finding showed evident residual tumour at 60 Gy of IMRT, then, boost HDR-ISBT was proposed. After delivering 66 Gy of IMRT, CT image-guided HDR-ISBT 4 Gy in a single fraction was performed under local anaesthesia and sedation. MRI taken 5 months after HDR-ISBT showed remarkable shrinkage of the primary tumour. After HDR-ISBT, the remaining session of IMRT was delivered from the next day until 70 Gy in 35 fractions. It was demonstrated that boost HDR-ISBT combined with IMRT for keratinizing squamous cell carcinoma of the nasopharynx was performed safely and showed favourable efficacy. The British Institute of Radiology. 2020-08-21 /pmc/articles/PMC7709071/ /pubmed/33299579 http://dx.doi.org/10.1259/bjrcr.20200005 Text en © 2020 The Authors. Published by the British Institute of Radiology This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Murakami, Naoya
Yoshimoto, Seiichi
Uematsu, Masakazu
Kashihara, Tairo
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Igaki, Hiroshi
Nakayama, Yuko
Masui, Koji
Yoshida, Ken
Itami, Jun
Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx
title Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx
title_full Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx
title_fullStr Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx
title_full_unstemmed Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx
title_short Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx
title_sort image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709071/
https://www.ncbi.nlm.nih.gov/pubmed/33299579
http://dx.doi.org/10.1259/bjrcr.20200005
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