Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering

Background: Native cluster of differentiation (CD) 19 targeting antibodies are poorly effective in triggering antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are crucial effector functions of therapeutic antibodies in cancer immunotherapy. Both...

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Detalles Bibliográficos
Autores principales: Roßkopf, Sophia, Eichholz, Klara Marie, Winterberg, Dorothee, Diemer, Katarina Julia, Lutz, Sebastian, Münnich, Ira Alexandra, Klausz, Katja, Rösner, Thies, Valerius, Thomas, Schewe, Denis Martin, Humpe, Andreas, Gramatzki, Martin, Peipp, Matthias, Kellner, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709100/
https://www.ncbi.nlm.nih.gov/pubmed/33212776
http://dx.doi.org/10.3390/antib9040063

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