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Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures

Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for togg...

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Autores principales: Yang, Haoxiang, Sürer, Özge, Duque, Daniel, Morton, David P., Singh, Bismark, Fox, Spencer J., Pasco, Remy, Pierce, Kelly, Rathouz, Paul, Du, Zhanwei, Pignone, Michael, Escott, Mark E., Adler, Stephen I., Johnston, S. Claiborne, Meyers, Lauren Ancel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709193/
https://www.ncbi.nlm.nih.gov/pubmed/33269372
http://dx.doi.org/10.1101/2020.11.26.20152520
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author Yang, Haoxiang
Sürer, Özge
Duque, Daniel
Morton, David P.
Singh, Bismark
Fox, Spencer J.
Pasco, Remy
Pierce, Kelly
Rathouz, Paul
Du, Zhanwei
Pignone, Michael
Escott, Mark E.
Adler, Stephen I.
Johnston, S. Claiborne
Meyers, Lauren Ancel
author_facet Yang, Haoxiang
Sürer, Özge
Duque, Daniel
Morton, David P.
Singh, Bismark
Fox, Spencer J.
Pasco, Remy
Pierce, Kelly
Rathouz, Paul
Du, Zhanwei
Pignone, Michael
Escott, Mark E.
Adler, Stephen I.
Johnston, S. Claiborne
Meyers, Lauren Ancel
author_sort Yang, Haoxiang
collection PubMed
description Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for toggling between mitigation stages using daily COVID-19 hospital admissions. With public compliance, the policy triggers ensure adequate intensive care unit capacity with high probability while minimizing the duration of strict mitigation measures. In comparison, we show that other sensible COVID-19 staging policies, including France’s ICU-based thresholds and a widely adopted indicator for reopening schools and businesses, require overly restrictive measures or trigger strict stages too late to avert catastrophic surges. As cities worldwide face future pandemic waves, our findings provide a robust strategy for tracking COVID-19 hospital admissions as an early indicator of hospital surges and enacting staged measures to ensure integrity of the health system, safety of the health workforce, and public confidence.
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spelling pubmed-77091932020-12-03 Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures Yang, Haoxiang Sürer, Özge Duque, Daniel Morton, David P. Singh, Bismark Fox, Spencer J. Pasco, Remy Pierce, Kelly Rathouz, Paul Du, Zhanwei Pignone, Michael Escott, Mark E. Adler, Stephen I. Johnston, S. Claiborne Meyers, Lauren Ancel medRxiv Article Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for toggling between mitigation stages using daily COVID-19 hospital admissions. With public compliance, the policy triggers ensure adequate intensive care unit capacity with high probability while minimizing the duration of strict mitigation measures. In comparison, we show that other sensible COVID-19 staging policies, including France’s ICU-based thresholds and a widely adopted indicator for reopening schools and businesses, require overly restrictive measures or trigger strict stages too late to avert catastrophic surges. As cities worldwide face future pandemic waves, our findings provide a robust strategy for tracking COVID-19 hospital admissions as an early indicator of hospital surges and enacting staged measures to ensure integrity of the health system, safety of the health workforce, and public confidence. Cold Spring Harbor Laboratory 2020-12-24 /pmc/articles/PMC7709193/ /pubmed/33269372 http://dx.doi.org/10.1101/2020.11.26.20152520 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Yang, Haoxiang
Sürer, Özge
Duque, Daniel
Morton, David P.
Singh, Bismark
Fox, Spencer J.
Pasco, Remy
Pierce, Kelly
Rathouz, Paul
Du, Zhanwei
Pignone, Michael
Escott, Mark E.
Adler, Stephen I.
Johnston, S. Claiborne
Meyers, Lauren Ancel
Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures
title Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures
title_full Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures
title_fullStr Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures
title_full_unstemmed Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures
title_short Design of COVID-19 Staged Alert Systems to Ensure Healthcare Capacity with Minimal Closures
title_sort design of covid-19 staged alert systems to ensure healthcare capacity with minimal closures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709193/
https://www.ncbi.nlm.nih.gov/pubmed/33269372
http://dx.doi.org/10.1101/2020.11.26.20152520
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