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Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain

BACKGROUND: Periventricular leukomalacia (PVL), a devastating brain injury affecting premature infants, is the most common cause of cerebral palsy. PVL is caused by hypoxia ischemia (HI) and is characterized by white matter necrotic lesions, microglial activation, upregulation of NF-κB, and neuronal...

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Detalles Bibliográficos
Autores principales:	Zaghloul, Nahla, Kurepa, Dalibor, Bader, Mohammad Y., Nagy, Nadia, Ahmed, Mohamed N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709340/ https://www.ncbi.nlm.nih.gov/pubmed/33261624 http://dx.doi.org/10.1186/s12974-020-02031-9

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