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Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China

OBJECTIVE: To assess the impact of heart disease (HD) combined with depression on all-cause mortality in older people living in the community. DESIGN: A population-based cohort study. PARTICIPANTS: We examined the data of 1429 participants aged ≥60 years recruited in rural areas in Anhui province, C...

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Autores principales: Zhou, Weiju, Hopkins, Alex, Zaman, M Justin, Tao, Xuguang (Grant), Rodney, Amanda, Yao, Yuyou, Cao, Zhongqiang, Ma, Ying, Hu, Zhi, Copeland, John J, Chen, Ruoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709510/
https://www.ncbi.nlm.nih.gov/pubmed/33262187
http://dx.doi.org/10.1136/bmjopen-2020-038341
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author Zhou, Weiju
Hopkins, Alex
Zaman, M Justin
Tao, Xuguang (Grant)
Rodney, Amanda
Yao, Yuyou
Cao, Zhongqiang
Ma, Ying
Hu, Zhi
Copeland, John J
Chen, Ruoling
author_facet Zhou, Weiju
Hopkins, Alex
Zaman, M Justin
Tao, Xuguang (Grant)
Rodney, Amanda
Yao, Yuyou
Cao, Zhongqiang
Ma, Ying
Hu, Zhi
Copeland, John J
Chen, Ruoling
author_sort Zhou, Weiju
collection PubMed
description OBJECTIVE: To assess the impact of heart disease (HD) combined with depression on all-cause mortality in older people living in the community. DESIGN: A population-based cohort study. PARTICIPANTS: We examined the data of 1429 participants aged ≥60 years recruited in rural areas in Anhui province, China. Using a standard method of interview, we documented all types of HD diagnosed by doctors and used the validated Geriatric Mental Status-Automated Geriatric Examination for Computer Assisted Taxonomy algorithm to diagnose any depression for each participant at baseline in 2003. The participants were followed up for 8 years to identify vital status. MEASUREMENTS: We sought to examine all-cause mortality rates among participants with HD only, depression only and then their combination compared with those without these diseases using multivariate adjusted Cox regression models. RESULTS: 385 deaths occurred in the cohort follow-up. Participants with baseline HD (n=91) had a significantly higher mortality (64.9 per 1000 person-years) than those without HD (42.9). In comparison to those without HD and depression, multivariate adjusted HRs for mortality in the groups of participants who had HD only, depression only and both HD and depression were 1.46 (95% CI 0.98 to 2.17), 1.79 (95% CI 1.28 to 2.48) and 2.59 (95% CI 1.12 to 5.98), respectively. CONCLUSION: Older people with both HD and depression in China had significantly increased all-cause mortality compared with those with HD or depression only, and without either condition. Psychological interventions should be taken into consideration for older people and those with HD living in the community to improve surviving outcome.
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spelling pubmed-77095102020-12-09 Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China Zhou, Weiju Hopkins, Alex Zaman, M Justin Tao, Xuguang (Grant) Rodney, Amanda Yao, Yuyou Cao, Zhongqiang Ma, Ying Hu, Zhi Copeland, John J Chen, Ruoling BMJ Open Epidemiology OBJECTIVE: To assess the impact of heart disease (HD) combined with depression on all-cause mortality in older people living in the community. DESIGN: A population-based cohort study. PARTICIPANTS: We examined the data of 1429 participants aged ≥60 years recruited in rural areas in Anhui province, China. Using a standard method of interview, we documented all types of HD diagnosed by doctors and used the validated Geriatric Mental Status-Automated Geriatric Examination for Computer Assisted Taxonomy algorithm to diagnose any depression for each participant at baseline in 2003. The participants were followed up for 8 years to identify vital status. MEASUREMENTS: We sought to examine all-cause mortality rates among participants with HD only, depression only and then their combination compared with those without these diseases using multivariate adjusted Cox regression models. RESULTS: 385 deaths occurred in the cohort follow-up. Participants with baseline HD (n=91) had a significantly higher mortality (64.9 per 1000 person-years) than those without HD (42.9). In comparison to those without HD and depression, multivariate adjusted HRs for mortality in the groups of participants who had HD only, depression only and both HD and depression were 1.46 (95% CI 0.98 to 2.17), 1.79 (95% CI 1.28 to 2.48) and 2.59 (95% CI 1.12 to 5.98), respectively. CONCLUSION: Older people with both HD and depression in China had significantly increased all-cause mortality compared with those with HD or depression only, and without either condition. Psychological interventions should be taken into consideration for older people and those with HD living in the community to improve surviving outcome. BMJ Publishing Group 2020-12-01 /pmc/articles/PMC7709510/ /pubmed/33262187 http://dx.doi.org/10.1136/bmjopen-2020-038341 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Zhou, Weiju
Hopkins, Alex
Zaman, M Justin
Tao, Xuguang (Grant)
Rodney, Amanda
Yao, Yuyou
Cao, Zhongqiang
Ma, Ying
Hu, Zhi
Copeland, John J
Chen, Ruoling
Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China
title Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China
title_full Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China
title_fullStr Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China
title_full_unstemmed Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China
title_short Impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in China
title_sort impacts of heart disease, depression and their combination on all-cause mortality in older people: a rural community-based cohort study in china
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709510/
https://www.ncbi.nlm.nih.gov/pubmed/33262187
http://dx.doi.org/10.1136/bmjopen-2020-038341
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