Cargando…

Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire

The pharynx of the child may serve as a reservoir of pathogenic bacteria, including beta-haemolytic group A streptococci (GAS), which can give rise to upper airway infections and post-streptococcal diseases. The objective of this study was to determine the prevalence of beta-haemolytic Streptococcus...

Descripción completa

Detalles Bibliográficos
Autores principales: Monemo, Pacôme, Demba, Nadia, Touré, Fidèle S., Traoré, Adjartou, Avi, Christelle, N’Guessan, Micheline A., Tadet, Juste O., Gobey, Arthur R., Anoh, Augustin E., Diarrassouba, Abdoulaye, Tuo, Marie N., Cissé, Amadou, Saric, Jasmina, Utzinger, Jürg, Tia, Honoré, Kouassi-N’Djeundo, Judith, Becker, Sören L., Akoua-Koffi, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709589/
https://www.ncbi.nlm.nih.gov/pubmed/33261048
http://dx.doi.org/10.3390/tropicalmed5040177
_version_ 1783617781612150784
author Monemo, Pacôme
Demba, Nadia
Touré, Fidèle S.
Traoré, Adjartou
Avi, Christelle
N’Guessan, Micheline A.
Tadet, Juste O.
Gobey, Arthur R.
Anoh, Augustin E.
Diarrassouba, Abdoulaye
Tuo, Marie N.
Cissé, Amadou
Saric, Jasmina
Utzinger, Jürg
Tia, Honoré
Kouassi-N’Djeundo, Judith
Becker, Sören L.
Akoua-Koffi, Chantal
author_facet Monemo, Pacôme
Demba, Nadia
Touré, Fidèle S.
Traoré, Adjartou
Avi, Christelle
N’Guessan, Micheline A.
Tadet, Juste O.
Gobey, Arthur R.
Anoh, Augustin E.
Diarrassouba, Abdoulaye
Tuo, Marie N.
Cissé, Amadou
Saric, Jasmina
Utzinger, Jürg
Tia, Honoré
Kouassi-N’Djeundo, Judith
Becker, Sören L.
Akoua-Koffi, Chantal
author_sort Monemo, Pacôme
collection PubMed
description The pharynx of the child may serve as a reservoir of pathogenic bacteria, including beta-haemolytic group A streptococci (GAS), which can give rise to upper airway infections and post-streptococcal diseases. The objective of this study was to determine the prevalence of beta-haemolytic Streptococcus spp. in pharyngeal samples stemming from children aged 3–14 years in Bouaké, central Côte d’Ivoire. Oropharyngeal throat swabs for microbiological culture and venous blood samples to determine the seroprevalence of antistreptolysin O antibodies (ASO) were obtained from 400 children in March 2017. Identification was carried out using conventional bacteriological methods. Serogrouping was performed with a latex agglutination test, while an immunological agglutination assay was employed for ASO titres. The mean age of participating children was 9 years (standard deviation 2.5 years). In total, we detected 190 bacteria in culture, with 109 beta-haemolytic Streptococcus isolates, resulting in an oropharyngeal carriage rate of 27.2%. Group C streptococci accounted for 82.6% of all isolates, whereas GAS were rarely found (4.6%). The ASO seroprevalence was 17.3%. There was no correlation between serology and prevalence of streptococci (p = 0.722). In conclusion, there is a high pharyngeal carriage rate of non-GAS strains in children from Bouaké, warranting further investigation.
format Online
Article
Text
id pubmed-7709589
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77095892020-12-03 Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire Monemo, Pacôme Demba, Nadia Touré, Fidèle S. Traoré, Adjartou Avi, Christelle N’Guessan, Micheline A. Tadet, Juste O. Gobey, Arthur R. Anoh, Augustin E. Diarrassouba, Abdoulaye Tuo, Marie N. Cissé, Amadou Saric, Jasmina Utzinger, Jürg Tia, Honoré Kouassi-N’Djeundo, Judith Becker, Sören L. Akoua-Koffi, Chantal Trop Med Infect Dis Article The pharynx of the child may serve as a reservoir of pathogenic bacteria, including beta-haemolytic group A streptococci (GAS), which can give rise to upper airway infections and post-streptococcal diseases. The objective of this study was to determine the prevalence of beta-haemolytic Streptococcus spp. in pharyngeal samples stemming from children aged 3–14 years in Bouaké, central Côte d’Ivoire. Oropharyngeal throat swabs for microbiological culture and venous blood samples to determine the seroprevalence of antistreptolysin O antibodies (ASO) were obtained from 400 children in March 2017. Identification was carried out using conventional bacteriological methods. Serogrouping was performed with a latex agglutination test, while an immunological agglutination assay was employed for ASO titres. The mean age of participating children was 9 years (standard deviation 2.5 years). In total, we detected 190 bacteria in culture, with 109 beta-haemolytic Streptococcus isolates, resulting in an oropharyngeal carriage rate of 27.2%. Group C streptococci accounted for 82.6% of all isolates, whereas GAS were rarely found (4.6%). The ASO seroprevalence was 17.3%. There was no correlation between serology and prevalence of streptococci (p = 0.722). In conclusion, there is a high pharyngeal carriage rate of non-GAS strains in children from Bouaké, warranting further investigation. MDPI 2020-11-27 /pmc/articles/PMC7709589/ /pubmed/33261048 http://dx.doi.org/10.3390/tropicalmed5040177 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monemo, Pacôme
Demba, Nadia
Touré, Fidèle S.
Traoré, Adjartou
Avi, Christelle
N’Guessan, Micheline A.
Tadet, Juste O.
Gobey, Arthur R.
Anoh, Augustin E.
Diarrassouba, Abdoulaye
Tuo, Marie N.
Cissé, Amadou
Saric, Jasmina
Utzinger, Jürg
Tia, Honoré
Kouassi-N’Djeundo, Judith
Becker, Sören L.
Akoua-Koffi, Chantal
Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire
title Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire
title_full Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire
title_fullStr Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire
title_full_unstemmed Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire
title_short Pharyngeal Carriage of Beta-Haemolytic Streptococcus Species and Seroprevalence of Anti-Streptococcal Antibodies in Children in Bouaké, Côte d’Ivoire
title_sort pharyngeal carriage of beta-haemolytic streptococcus species and seroprevalence of anti-streptococcal antibodies in children in bouaké, côte d’ivoire
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709589/
https://www.ncbi.nlm.nih.gov/pubmed/33261048
http://dx.doi.org/10.3390/tropicalmed5040177
work_keys_str_mv AT monemopacome pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT dembanadia pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT tourefideles pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT traoreadjartou pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT avichristelle pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT nguessanmichelinea pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT tadetjusteo pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT gobeyarthurr pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT anohaugustine pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT diarrassoubaabdoulaye pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT tuomarien pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT cisseamadou pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT saricjasmina pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT utzingerjurg pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT tiahonore pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT kouassindjeundojudith pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT beckersorenl pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire
AT akouakoffichantal pharyngealcarriageofbetahaemolyticstreptococcusspeciesandseroprevalenceofantistreptococcalantibodiesinchildreninbouakecotedivoire