Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact

Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this vi...

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Detalles Bibliográficos
Autores principales: Jacob, Jobin John, Vasudevan, Karthick, Veeraraghavan, Balaji, Iyadurai, Ramya, Gunasekaran, Karthik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Journal of Medical Microbiology. Published by Elsevier B.V. 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709607/
https://www.ncbi.nlm.nih.gov/pubmed/32883935
http://dx.doi.org/10.4103/ijmm.IJMM_20_303
Descripción
Sumario:Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser, the candidate vaccines expected to have wide coverage worldwide including India.

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