Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact

Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this vi...

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Autores principales: Jacob, Jobin John, Vasudevan, Karthick, Veeraraghavan, Balaji, Iyadurai, Ramya, Gunasekaran, Karthik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Journal of Medical Microbiology. Published by Elsevier B.V. 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709607/
https://www.ncbi.nlm.nih.gov/pubmed/32883935
http://dx.doi.org/10.4103/ijmm.IJMM_20_303
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author Jacob, Jobin John
Vasudevan, Karthick
Veeraraghavan, Balaji
Iyadurai, Ramya
Gunasekaran, Karthik
author_facet Jacob, Jobin John
Vasudevan, Karthick
Veeraraghavan, Balaji
Iyadurai, Ramya
Gunasekaran, Karthik
author_sort Jacob, Jobin John
collection PubMed
description Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser, the candidate vaccines expected to have wide coverage worldwide including India.
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spelling pubmed-77096072020-12-03 Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact Jacob, Jobin John Vasudevan, Karthick Veeraraghavan, Balaji Iyadurai, Ramya Gunasekaran, Karthik Indian J Med Microbiol Brief Communication Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser, the candidate vaccines expected to have wide coverage worldwide including India. Indian Journal of Medical Microbiology. Published by Elsevier B.V. 2020 2020-12-02 /pmc/articles/PMC7709607/ /pubmed/32883935 http://dx.doi.org/10.4103/ijmm.IJMM_20_303 Text en Copyright © 2020 Indian Journal of Medical Microbiology. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Brief Communication
Jacob, Jobin John
Vasudevan, Karthick
Veeraraghavan, Balaji
Iyadurai, Ramya
Gunasekaran, Karthik
Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact
title Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact
title_full Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact
title_fullStr Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact
title_full_unstemmed Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact
title_short Genomic Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 in India and Vaccine Impact
title_sort genomic evolution of severe acute respiratory syndrome coronavirus 2 in india and vaccine impact
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709607/
https://www.ncbi.nlm.nih.gov/pubmed/32883935
http://dx.doi.org/10.4103/ijmm.IJMM_20_303
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