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Paediatric COVID-19 and the GUT

Although children with novel coronavirus infection (COVID-19) typically present with fever and respiratory symptoms, some children have reported gastrointestinal (GI) symptoms including vomiting and diarrhoea during the course of the disease. The continuous positive detection of the viral RNA from f...

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Autores principales: Gupta, Rohit, Beg, Saman, Jain, Alok, Bhatnagar, Shrish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Journal of Medical Microbiology. Published by Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709654/
https://www.ncbi.nlm.nih.gov/pubmed/33154233
http://dx.doi.org/10.4103/ijmm.IJMM_20_331
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author Gupta, Rohit
Beg, Saman
Jain, Alok
Bhatnagar, Shrish
author_facet Gupta, Rohit
Beg, Saman
Jain, Alok
Bhatnagar, Shrish
author_sort Gupta, Rohit
collection PubMed
description Although children with novel coronavirus infection (COVID-19) typically present with fever and respiratory symptoms, some children have reported gastrointestinal (GI) symptoms including vomiting and diarrhoea during the course of the disease. The continuous positive detection of the viral RNA from faeces in children even after nasopharyngeal swabs turned negative suggests that the GI tract may shed virus and a tentative faecal–oral transmission. The presence of angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2, which are the key proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry process, in the GI tract can explain the digestive symptoms in COVID-19. COVID-19 has implications for the management of children with chronic luminal diseases. There is increasing concern regarding the risk that children with inflammatory bowel disease being infected with SARS-CoV-2.
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spelling pubmed-77096542020-12-03 Paediatric COVID-19 and the GUT Gupta, Rohit Beg, Saman Jain, Alok Bhatnagar, Shrish Indian J Med Microbiol Review Article - Covid-19 Series Although children with novel coronavirus infection (COVID-19) typically present with fever and respiratory symptoms, some children have reported gastrointestinal (GI) symptoms including vomiting and diarrhoea during the course of the disease. The continuous positive detection of the viral RNA from faeces in children even after nasopharyngeal swabs turned negative suggests that the GI tract may shed virus and a tentative faecal–oral transmission. The presence of angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2, which are the key proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry process, in the GI tract can explain the digestive symptoms in COVID-19. COVID-19 has implications for the management of children with chronic luminal diseases. There is increasing concern regarding the risk that children with inflammatory bowel disease being infected with SARS-CoV-2. Indian Journal of Medical Microbiology. Published by Elsevier B.V. 2020 2020-12-02 /pmc/articles/PMC7709654/ /pubmed/33154233 http://dx.doi.org/10.4103/ijmm.IJMM_20_331 Text en Copyright © 2020 Indian Journal of Medical Microbiology. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article - Covid-19 Series
Gupta, Rohit
Beg, Saman
Jain, Alok
Bhatnagar, Shrish
Paediatric COVID-19 and the GUT
title Paediatric COVID-19 and the GUT
title_full Paediatric COVID-19 and the GUT
title_fullStr Paediatric COVID-19 and the GUT
title_full_unstemmed Paediatric COVID-19 and the GUT
title_short Paediatric COVID-19 and the GUT
title_sort paediatric covid-19 and the gut
topic Review Article - Covid-19 Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709654/
https://www.ncbi.nlm.nih.gov/pubmed/33154233
http://dx.doi.org/10.4103/ijmm.IJMM_20_331
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